人血白蛋白结合目标导向性液体疗法对脓毒症休克伴ARDS患者血气状态及炎症反应水平的影响  

Effect of Human Albumin Combined with Goal-Directed Fluid Therapy on Blood Gas Status and Inflammatory Response Levels in Patients with Septic Shock with Ards

作　　者：王婷婷 张子书 WANG Tingting;ZHANG Zishu(Department of Respiratory Medicine,Xiangshui People's Hospital,Jiangsu Province,Xiangshui 224600,China)

机构地区：[1]江苏省响水县人民医院呼吸内科,江苏盐城224600

出　　处：《转化医学杂志》2024年第11期1838-1842,共5页Translational Medicine Journal

基　　金：江苏省卫生健康委科研项目(H2020126)。

摘　　要：目的分析人血白蛋白结合目标导向性液体疗法对脓毒症休克伴呼吸窘迫综合征(ARDS)患者的治疗效果。方法采用回顾研究分析法。回顾102例江苏省响水县人民医院就诊的脓毒症休克伴ARDS患者相关资料。依据其治疗方案的不同进行分组,对照组50例,应用目标导向性液体疗法;观察组52例,在对照组的治疗方案上应用人血白蛋白;对比两组治疗效果、血气分析、炎症表达等。结果观察组6 h、24 h补液达标率82.69%、92.31%均高于对照组的56.00%、74.00%,早期容量达标时间、24 h补液量、血管活性药物使用时间、机械通气时间均低于对照组(P<0.05)。观察组治疗24 h白蛋白含量高于对照组,治疗24 h动脉血氧分压(PaO2)、中心静脉血氧饱和度均高于对照组,血清炎症低于对照组(P<0.05)。结论人血白蛋白结合目标导向性液体疗法可提高脓毒症休克伴ARDS患者早期补液达标率,改善其血气分析,降低炎症表达水平,值得应用。Objective To analyse the therapeutic effect of human albumin combined with goal-directed fluid therapy in patients with septic shock with respiratory distress syndrome(ARDS).Methods A retrospective study analysis method was used.The data related to 102 patients with septic shock with ARDS attending the People's Hospital of Langshui County,Jiangsu Province were reviewed.They were grouped according to their different treatment programs,50 cases in the control group,applying goal-directed fluid therapy;52 cases in the observation group,applying human albumin on the treatment program of the control group;and comparing the treatment effect,blood gas analysis and inflammation expression of the two groups.Results The 6 h and 24 h rehydration rate of 82.69%and 92.31%in the observation group was higher than that of 56.00%and 74.00%in the control group,and the time of early volume attainment,24 h rehydration volume,time of vasoactive drug use,and time of mechanical ventilation were lower than that of the control group(P<0.05).The albumin content of the observation group for 24 h of treatment was higher than that of the control group,the partial pressure of arterial oxygen(PaO2)and central venous oxygen saturation for 24 h of treatment were higher than that of the control group,and serum inflammation was lower than that of the control group(P<0.05).Conclusion Human albumin combined with goal-directed fluid therapy improves early rehydration compliance,improves their blood gas analysis and reduces the level of inflammatory expression in patients with septic shock with ARDS,and is worth applying.

关 键 词：人血白蛋白 目标导向性液体疗法 脓毒症休克 呼吸窘迫综合征 

分 类 号：R631.4[医药卫生—外科学]