基于Logistic回归方程分析早、晚期足月小样儿神经行为发育的围生期影响因素及干预对策  

Analysis of Perinatal Influencing Factors on Neurobehavioral Development of Early and Late Term Small-for-Gestational-Age Infants Based on Logistic Regression Equations and Intervention Countermeasures

作　　者：李洁 何颖 范雪爱 LI Jie;HE Ying;FAN Xueai(Department of Child Health Care,Xingtai Central Hospital,Xingtai,Hebei 054000,China)

机构地区：[1]邢台市中心医院儿童保健科,河北邢台054000

出　　处：《转化医学杂志》2024年第11期1894-1898,共5页Translational Medicine Journal

基　　金：邢台市重点研发计划项目(2022zz082)。

摘　　要：目的基于Logistic回归方程分析早期和晚期足月小样儿神经行为发育的围生期影响因素,并提出有关干预对策。方法回顾性收集2022年1月至2023年12月邢台市第三医院分娩的早期和晚期足月小样儿设为观察组,另收集同时间段本院分娩的健康足月儿设为对照组,比较2组生后3~7 d中文版Hammersmith婴儿神经学检查量表(HINE)量表得分,并依据HINE量表得分将观察组分为神经行为发育良好组和不良组,比较两组围生期母婴资料差异,对存在差异指标经多元Logistic回归模型开展分析,明确影响神经行为发育早期和晚期足月小样儿的围生期因素,并制定相应干预措施。结果148例早期和晚期足月小样儿纳入观察组,150例健康足月儿纳入对照组。观察组颅神经、肌张力、运动、姿势、反射与反应方面的HINE量表得分及总分均低于对照组(P<0.05)。148例早期和晚期足月小样儿中,共25例神经行为发育不良纳入不良组,占16.89%;余123例发育良好纳入良好组,占83.11%。不良组和良好组在生时体重、有无高胆红素血症、有无孕母围生期感染、有无妊高症方面有统计学差异(P<0.05)。Logistic回归分析显示生时体重、胆红素血症、孕母围生期感染及妊高症均为影响早期和晚期足月小样儿神经行为发育的危险因素(OR值>1,P<0.05)。结论早期和晚期足月小样儿神经行为发育的影响因素包含生时体重、胆红素血症、孕母围生期感染以及妊高症,需要临床结合上述因素做好高危儿筛查工作,开展针对性干预,以改善其发育结局。Objective To analyze the perinatal influencing factors of neurobehavioral development of early and late full-term small-for-gestational-age infants based on Logistic regression equations,and to propose relevant intervention countermeasures.Methods We retrospectively collected early and late full-term infants delivered in Xingtai Third Hospital from January 2022 to December 2023 as the observation group,and retrospectively collected healthy full-term infants delivered in Xingtai Third Hospital in the same time period as the control group,and compared the scores of the Chinese version of the Hammersmith(HINE)scale in the first 3 to 7 days after birth of the two groups,and classified them into a good and a poor group according to the scores of the HINE scale.Based on the HINE scale scores,the observation group was divided into the neurobehavioral development good group and the poor group,and the perinatal data of mothers and infants of the two groups were compared,and the indicators of the differences were analyzed by the multivariate logistic regression model,so as to clarify the perinatal factors affecting the neurobehavioral development of the early and late full-term infants and to formulate the corresponding intervention measures.Results A total of 148 early and late term infants were included in the observation group,and 150 healthy term infants were included in the control group.The HINE scores and total scores of cranial nerves,muscle tone,movement,posture,reflexes and responses of the observation group were lower than those of the control group(P<0.05).25 cases of neurobehavioral dysplasia were included in the poor group among the 148 early and late term infants,which accounted for 16.89%,and the remaining 123 cases of good development were included in the good group,which accounted for 83.11%.There were statistically significant differences between the poor and good groups in terms of birth weight,the presence of hyperbilirubinemia,the presence of perinatal infections in the pregnant mother,and the presenc

关 键 词：足月小样儿 神经行为发育 围生期 影响因素 

分 类 号：R725.952[医药卫生—儿科]