围排卵期宫颈处理对宫颈黏液异常性不孕症患者妊娠结局的影响  

Effect of Periovulation Cervical Treatment on Pregnancy Outcomes in Patients with Abnormal Cervical Mucus Infertility

作　　者：郑江丽 董君 王会玲 葛欣欣 王会霞 ZHENG Jiangli;DONG Jun;WANG Huiling;GE Xinxin;WANG Huixia(Department of Reproduction,Hengshui Health School Affiliated Hospital,Hengshui,Hebei 053000,China)

机构地区：[1]衡水卫生学校附属医院生殖科,河北衡水053000

出　　处：《转化医学杂志》2024年第11期1927-1930,1935,共5页Translational Medicine Journal

基　　金：衡水市2023年度科技计划(2023014014Z)。

摘　　要：目的观察围排卵期宫颈处理对宫颈黏液异常性不孕症患者妊娠结局的影响。方法选取2020年6月至2023年6月于衡水卫生学校附属医院就诊的宫颈黏液异常性不孕症患者120例,经Excel产生随机序列号法分为药物治疗组(经芬吗通白片与维生素E胶丸进行宫颈处理)、人工授精组(宫颈内人工授精干预),各60例。比较2组干预前、干预后宫颈黏液评分及宫颈黏液白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平;比较2组妊娠率、不良反应。结果干预后药物治疗组宫颈黏液评分高于人工授精组(P<0.05);干预后药物治疗组宫颈黏液评分高于干预前(P<0.05);干预前、后人工授精组宫颈黏液评分无显著变化(P>0.05)。干预后药物治疗组宫颈黏液IL-6、TNF-α水平均低于人工授精组(P<0.05);干预后药物治疗组宫颈黏液IL-6、TNF-α水平均低于干预前(P<0.05);干预前、后人工授精组宫颈黏液IL-6、TNF-α水平无统计学差异(P>0.05)。药物治疗组妊娠率高于人工授精组(P<0.05)。2组均无明显不良反应。结论宫颈黏液异常性不孕症患者于围排卵期采用芬吗通白片与维生素E胶丸进行宫颈处理可改善宫颈黏液状态及妊娠结局,减轻宫颈黏液炎症,且不会增加不良反应。Objective To investigate the effect of cervical treatment during the periovulatory period on pregnancy outcomes in patients with cervical mucus-related infertility.Methods A total of 120 patients with cervical mucus-related infertility who visited the hospital from June 2020 to June 2023 were selected.They were randomly divided into Group A(cervical treatment with fenugreek white tablets and vitamin E capsules)and Group B(intervention with intracervical artificial insemination),with 60 cases in each group.The cervical mucus scores,as well as the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in cervical mucus,were compared before and after intervention in both groups.Additionally,pregnancy rates and adverse reactions were compared between the two groups.Results After intervention,the cervical mucus score in Group A was higher than that in Group B(P<0.05).The cervical mucus score in Group A after intervention was higher than before intervention(P<0.05).There was no significant change in cervical mucus scores before and after intervention in Group B(P>0.05).After intervention,the levels of IL-6 and TNF-αin cervical mucus in Group A were lower than those in Group B(P<0.05).The levels of IL-6 and TNF-αin cervical mucus in Group A after intervention were lower than those before intervention(P<0.05).There were no significant changes in the levels of IL-6 and TNF-αin cervical mucus before and after intervention in Group B(P>0.05).The pregnancy rate in Group A was higher than that in Group B(P<0.05).No significant adverse reactions were observed in either group.Conclusion Cervical treatment with fenugreek white tablets and vitamin E capsules during the periovulatory period can improve the state of cervical mucus and pregnancy outcomes in patients with cervical mucus-related infertility,reduce inflammation in cervical mucus,and does not increase adverse reactions.

关 键 词：宫颈黏液异常性不孕症 芬吗通 维生素E 妊娠结局 

分 类 号：R271.14[医药卫生—中医妇科学]