针刺联合温肾活血汤灌肠治疗输卵管阻塞性不孕的疗效及对血液流变学、粘连程度和炎性因子的影响  

The Therapeutic Effect of Acupuncture Combined with Wen Shen Huo Xue Decoction Enema on Tubal Obstructive Infertility and Its Impact on Hemorheology,Adhesion Degree,and Inflammatory Factors

作　　者：刘娜 宜莉 郭佳易 LIU Na;YI Li;GUO Jiayi(Department of Gynaecology,Yan'an Traditional Chinese Medicine Hospital,Yan'an,Shaanxi 716000,China)

机构地区：[1]延安市中医医院妇科,陕西延安716000

出　　处：《转化医学杂志》2024年第11期1995-1998,共4页Translational Medicine Journal

基　　金：陕西省中医药管理局(2021-GJ-LC015)。

摘　　要：目的探讨针刺联合温肾活血汤灌肠治疗输卵管阻塞性不孕的疗效及对血液流变学、粘连程度和炎性因子的影响。方法80例输卵管阻塞性不孕患者分为观察组与对照组,每组各40例。对照组以腹腔镜下输卵管整形术治疗,观察组在对照组基础上术后增加针刺联合温肾活血汤灌肠治疗,治疗3个疗程。评估对比2组临床疗效、中医证候积分、血液流变学、粘连指标、炎性因子水平。结果观察组总有效率高于对照组(P<0.05)。观察组中医证候积分均低于对照组(P<0.05)。治疗后,观察组全血黏度(BV)、血浆黏度(PV)、纤维蛋白原(FIB)、红细胞压积(HCT)均低于对照组(P<0.05)。治疗后,观察组透明质酸(HA)、Ⅲ型前胶原氨基端肽(PⅢNP)、层黏连蛋白(LN)均低于对照组(P<0.05)。治疗后,观察组炎性因子超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)均低于对照组(P<0.05)。结论针刺联合温肾活血汤灌肠治疗输卵管阻塞性不孕的效果良好,可提升患者临床疗效,降低中医证候积分、血液流变学、粘连程度和炎性因子水平。Objective To explore the efficacy of acupuncture combined with Wen Shen Huo Xue decoction enema in the treatment of tubal obstructive infertility,as well as its effects on hemorheology,adhesion degree,and inflammatory factors.Methods Eighty patients with tubal obstructive infertility were divided into an observation group and a control group,with 40 cases in each group.The control group was treated with laparoscopic tubal plastic surgery,while the observation group received acupuncture combined with Wen Shen Huo Xue decoction enema after surgery.The treatment lasted for 3 courses.The clinical efficacy,TCM syndrome scores,hemorheology,adhesion indicators,and inflammatory factor levels were evaluated and compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(P<0.05).The TCM syndrome scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the observation group showed lower values of whole blood viscosity(BV),plasma viscosity(PV),fibrinogen(FIB),and hematocrit(HCT)compared to the control group(P<0.05).The levels of hyaluronic acid(HA),PⅢNP,and laminin(LN)in the observation group were also lower than those in the control group(P<0.05).Additionally,the levels of inflammatory factors,including hypersensitive C-reactive protein(hs-CRP),interleukin 6(IL-6),and tumor necrosis factor-alpha(TNF-α)in the observation group were lower than those in the control group(P<0.05).Conclusion Acupuncture combined with Wen Shen Huo Xue decoction enema is effective in treating tubal obstructive infertility.It can improve clinical efficacy,reduce TCM syndrome scores,blood rheology,adhesion degree,and levels of inflammatory factors.

关 键 词：不孕症 输卵管阻塞 温肾活血汤 灌肠治疗 针刺治疗 血液流变学 粘连程度 炎性因子 

分 类 号：R271.14[医药卫生—中医妇科学]