羧基麦芽糖铁联合BIPAP呼吸机模式对急性心力衰竭患者治疗效果的研究  

The Impact of Ferric Carboxymaltose Combined with BIPAP Ventilation on the Treatment of Patients with Acute Heart Failure

作　　者：丁青亚 王健[2] DING Qingya;WANG Jian(Department of Critical Care Medicine,Linshui County Traditional Chinese Medicine Hospital,Guang'an,Sichuan 638500,China;Department of Critical Care Medicine,West China Hospital of Sichuan University,Guang'an Hospital,Guang'an,Sichuan 638001,China)

机构地区：[1]广安市邻水县中医医院重症医学科,四川广安638500 [2]四川大学华西医院广安医院重症医学科,四川广安638001

出　　处：《转化医学杂志》2024年第11期2015-2018,共4页Translational Medicine Journal

基　　金：四川省中医药管理局科学技术专项课题(2023MS609)。

摘　　要：目的探讨羧基麦芽糖铁联合BIPAP呼吸机对急性心力衰竭患者的治疗效果。方法选取2023年1月至2024年4月广安市邻水县中医医院收治的62例急性心力衰竭患者为研究对象,按住院号将其随机分为观察组(n=31)和对照组(n=31)。对照组采用BIPAP呼吸机治疗,观察组采用羧基麦芽糖铁+BIPAP呼吸机联合治疗。比较2组临床疗效和患者心功能、血浆B型利钠肽(BNP)、血压、血气分析以及不良反应发生情况。结果观察组总有效率高于对照组(93.55%vs 74.19%,χ2=4.29,P=0.04)。治疗后,2组心率、呼吸频率、血压、BNP、左心室射血分数(LVEF)、左心室舒张末容积(LVEDV)评分均明显改善,动脉血二氧化碳分压(PaCO_(2))降低,动脉血氧分压(PaO_(2))和血氧饱和度(SaO_(2))均升高,且观察组优于对照组,组间比较差异均具有统计学意义(P均<0.05)。结论羧基麦芽糖铁联合BIPAP呼吸机治疗急性心力衰竭疗效良好,可有效改善患者心力衰竭症状,稳定血压、血气和心功能,具有一定的临床应用价值。Objective To explore the therapeutic effect of ferric carboxymaltose combined with BIPAP ventilator on patients with acute heart failure.Methods A total of 62 patients with acute heart failure,admitted to Linshui County Traditional Chinese Medicine Hospital from January 2023 to April 2024,were randomly divided into an observation group(n=31)and a control group(n=31)according to hospital admission numbers.The control group was treated with BIPAP ventilator,while the observation group was treated with the combination of ferric carboxymaltose and BIPAP ventilator.The clinical efficacy,cardiac function,plasma B-type natriuretic peptide(BNP),blood pressure,blood gas analysis,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(93.55%vs 74.19%,χ2=4.29,P=0.04).After treatment,the heart rate,respiratory rate,blood pressure,BNP,left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),partial pressure of carbon dioxide in arterial blood(PaCO_(2)),partial pressure of oxygen in arterial blood(PaO_(2)),and oxygen saturation of hemoglobin in arterial blood(SaO_(2))of the two groups were significantly improved.The PaCO_(2)decreased,while the PaO_(2)and SaO_(2)increased,and the observation group was superior to the control group,and the differences between the groups were statistically significant(all P<0.05).Conclusion The combination of ferric carboxymaltose and BIPAP ventilator has a good effect in treating patients with acute heart failure.It can effectively improve the symptoms of heart failure,stabilize blood pressure,blood gas,and cardiac function,and has certain clinical application value.

关 键 词：羧基麦芽糖铁 BIPAP呼吸机 急性心力衰竭 B型利钠肽 

分 类 号：R541.62[医药卫生—心血管疾病]