谷胱甘肽-S-转移酶与肝脏疾病相关性研究进展  

Research Advances in the Association Between Glutathione S-Transferases and Hepatic Disorders

作　　者：袁烷茹 刘业彬 罗佳聪 刘书畅 姜晨辉 杨树龙 YUAN Wan-ru;LIU Ye-bin;LUO Jia-cong;LIU Shu-chang;JIANG Chen-hui;YANG Shu-long(School of Clinical Medical Sciences,Fuzhou Medical College of Nanchang University,Fuzhou 344000,China;School of Basic Medical Sciences,Fuzhou Medical College of Nanchang University,Fuzhou 344000,China)

机构地区：[1]南昌大学抚州医学院临床医学院,江西抚州344000 [2]南昌大学抚州医学院基础医学院,江西抚州344000

出　　处：《实用临床医学(江西)》2025年第1期120-125,共6页Practical Clinical Medicine

基　　金：国家自然科学基金(82360880,82060661);江西省自然科学基金(20232ACB206057);江西省教育厅科技研究重点项目(GJJ218104);江西省教育厅科技研究项目(GJJ2203409)。

摘　　要：谷胱甘肽-S-转移酶(GST)是属于Ⅱ期解毒酶超基因家族的酶类,广泛存在于各种类型的细胞中,参与多种生理活动。GST通过催化致癌剂或增加氧化应激来诱导细胞凋亡,且在药物性肝病和肝癌的发生发展中发挥重要作用。抑制GST活性可促进肝病的发生,而提高GST水平则可抑制致癌作用,增强肝脏的解毒能力,并提高其抗氧化应激能力,有助于防治药物性肝病和肝癌。此外,GST还具有调控细胞信号转导通路、治疗肝脂肪变性以及抑制黄曲霉毒素诱导的肝细胞凋亡等功能。文章综述了近年来关于GST在肝脏疾病中双重作用的研究进展,为临床筛查、预防和治疗肝病提供新的思路。Glutathione S-transferases(GSTs),members of the PhaseⅡdetoxification enzyme supergene family,are ubiquitously expressed across virtually all cellular systems,participating in multifaceted physiological processes.Current evidence indicates that GSTs induce apoptosis through catalyzing carcinogen metabolism and potentiating oxidative stress,while playing pivotal roles in the pathogenesis of drug-induced liver injury(DILI)and hepatocellular carcinoma(HCC).Inhibition of GST activity may exacerbate hepatopathogenesis,whereas GST upregulation could potentially suppress carcinogenesis,enhance hepatic detoxification capacity,and augment antioxidative stress competence,thereby contributing to therapeutic strategies against DILI and HCC.Additionally,GSTs demonstrate regulatory functions in cellular signaling transduction pathways,exhibit therapeutic potential for hepatic steatosis,and inhibit aflatoxin-induced hepatocyte apoptosis.This review synthesizes recent advances in understanding the dual regulatory mechanisms of GSTs in hepatic disorders,offering novel perspectives for clinical screening,preventive interventions,and therapeutic management of liver diseases.

关 键 词：谷胱甘肽-S-转移酶 肝损伤 肝保护 细胞凋亡 

分 类 号：R333.4[医药卫生—人体生理学]