多囊卵巢综合征患者腹型肥胖、高雄激素血症、胰岛素抵抗及脂代谢异常的相关性分析  

Correlation analysis of abdominal obesity,hyperandrogenemia,insulin resistance and lipid metabolism in patients with polycystic ovary syndrome

作　　者：李翠芹 LI Cuiqin(Department of Women's Health,Xuzhou Maternal and Child Health Hospital,Xuzhou 221000,China)

机构地区：[1]徐州市妇幼保健院妇女保健科,江苏徐州221000

出　　处：《延边大学医学学报》2025年第1期18-20,共3页Journal of Medical Science Yanbian University

摘　　要：目的:探讨多囊卵巢综合征(PCOS)患者腹型肥胖、高雄激素血症、胰岛素抵抗及脂代谢异常之间的相关性。方法:通过对比分析60例PCOS患者(观察组)与60例健康女性(对照组)的临床资料,采用单因素与多因素Logistic回归分析,研究各组在腹型肥胖指标、高雄激素血症生化特征、胰岛素抵抗程度及脂代谢参数的差异。结果:观察组腰围、臀围、腰臀比(WHR)、血清睾酮(T)水平、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均高于对照组(P<0.05),观察组高密度脂蛋白胆固醇(HDL-C)水平低于对照组(P<0.05)。经多因素Logistic回归分析,腹型肥胖、高雄激素血症和胰岛素抵抗均是PCOS患者脂代谢异常的独立风险因素(P<0.001)。结论:PCOS的发生与腹型肥胖、高雄激素血症、胰岛素抵抗及脂代谢异常之间存在密切联系。objective:To investigate the correlation between abdominal obesity,hyperandrogenemia,insulin resistance and abnormal lipid metabolism in patients with polycystic ovary syndrome(PCOS).Methods:By comparing and analyzing the clinical data of 60 PCOS patients(observation group)and 60 healthy women(control group),single factor and multiple factor logistic regression analysis were used to study the differences in abdominal obesity index,biochemical characteristics of hyperandrogenism,degree of insulin resistance,and lipid metabolism parameters between the two groups.Results:The waist circumference,hip circumference,waist-to-hip ratio(WHR),serum testosterone(T)levels,homeostasis model assessment of insulin resistance(HOMA-IR),total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)levels in the observation group were all higher than those in the control group(P<0.05),while the high-density lipoprotein cholesterol(HDL-C)levels in the observation group were lower than those in the control group(P<0.05).According to multiple logistic regression analysis,abdominal obesity,hyperandrogenism,and insulin resistance were independent risk factors for lipid metabolism abnormalities in PCOS patients(P<0.001).Conclusion:This study reveals that the occurrence of PCOS is closely related to abdominal obesity,hyperandrogenemia,insulin resistance and abnormal lipid metabolism.

关 键 词：多囊卵巢综合征 腹型肥胖 高雄激素血症 胰岛素抵抗 脂代谢异常 

分 类 号：R711[医药卫生—妇产科学]