颈动脉超声参数、血清25-羟维生素D水平对糖尿病合并ASCVD的诊断价值  

Diagnostic value of carotid artery ultrasound parameters combined with serum 25-hydroxyvitamin D level for diabetes with ASCVD

作　　者：魏玲杰 WEI Lingjie(Department of Functional Medicine,Anyang Regional Hospital in Puyang,Anyang 455000,China)

机构地区：[1]濮阳市安阳地区医院功能科,河南安阳455000

出　　处：《延边大学医学学报》2025年第1期58-61,共4页Journal of Medical Science Yanbian University

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20191291)。

摘　　要：目的:探究颈动脉超声参数联合血清25-羟维生素D[25(OH)D]水平检测对糖尿病患者并发动脉粥样硬化性心血管疾病(ASCVD)的诊断价值。方法:收集2023年1月—2024年1月于濮阳市安阳地区医院就诊的139例糖尿病患者作为研究对象,根据是否出现ASCVD将其分为糖尿病组(68例)、合并组(71例),比较两组入院时一般资料、颈动脉超声参数及血清25(OH)D水平,采用Logistic多因素回归、受试者工作特性(ROC)曲线分析糖尿病患者合并ASCVD的危险因素及上述指标的诊断价值。结果:糖尿病组病程≥5年、FRS发病风险>10%占比小于合并组(P<0.05);合并组颈动脉内膜中层厚度(IMT)、斑块积分高于糖尿病组(P<0.05),血清25(OH)D水平低于糖尿病组(P<0.05);病程≥5年、FRS发病风险>10%、IMT、斑块积分较高、血清25(OH)D水平较低为糖尿病患者并发ASCVD的影响因素(P<0.05);颈动脉超声参数联合血清25(OH)D水平检测诊断糖尿病并发ASCVD的曲线下面积(AUC)为0.934,诊断敏感度为88.73%,特异度为83.82%。结论:颈动脉超声参数、血清25(OH)D水平联合诊断可为临床诊断糖尿病并发ASCVD提供有效参考依据。Objective:To investigate the diagnostic value of carotid artery ultrasound parameters combined with serum 25-hydroxyvitamin D[25(OH)D]level in diabetic patients with atherosclerotic cardiovascular disease(ASCVD).Methods:139 diabetic patients admitted to Anyang Regional Hospital from January 2023 to January 2024 were collected as study subjects,and they were divided into the diabetic group(68 cases)and the combined group(71 cases)according to whether they presented with ASCVD or not.The general data,carotid ultrasound parameters,and serum 25(OH)D level of the two groups were compared at the time of admission.The risk factors of diabetes patients with ASCVD and the diagnostic value of the above indexes were analyzed by logistic multivariate regression and receiver operating characteristic(ROC)curve.Results:The proportion of patients with a diabetes duration of≥5 years and a FRS risk of>10%in the diabetic group was lower than that in the combined group(P<0.05).The IMT and plaque score in the combined group were higher than those in the diabetic group(P<0.05),while the serum 25(OH)D level was lower than that in the diabetes group(P<0.05).Disease duration,FRS risk of onset>10%,IMT,plaque score,and serum 25(OH)D level are risk factors for diabetes patients with ASCVD(P<0.05).The AUC of carotid ultrasound parameters combined with serum 25(OH)D level in the diagnosis of diabetes complicated with ASCVD was 0.934,the diagnostic sensitivity was 88.73%,and the specificity was 83.82%.Conclusion:The joint diagnosis of carotid ultrasound parameters and serum 25(OH)D level can provide an effective reference for the clinical diagnosis of diabetes with ASCVD.

关 键 词：糖尿病 动脉粥样硬化性心血管疾病 颈动脉超声 25-羟维生素D 

分 类 号：R446[医药卫生—诊断学]