大川芎口服液与通天口服液治疗中风恢复期的Meta分析和成本-效果分析  

Meta Analysis and Cost-effectiveness Analysis of Dachuanxiong Oral Liquid and Tongtian Oral Liquid in the Treatment of Convalescent Stroke

作　　者：张士勤 郭辉[2] 李永霞[2] ZHANG Shi-Qin;GUO Hui;LI Yong-Xia(Boya Intelligent Health Research Institute,Beijing 100080,China;Department of Emergency Medicine,Shanghai No.6 People's Hospital,Shanghai 200233,China)

机构地区：[1]博雅智汇大健康研究院,北京100080 [2]上海市第六人民医院急诊医学科,上海200233

出　　处：《中国药物经济学》2025年第1期12-17,23,共7页China Journal of Pharmaceutical Economics

摘　　要：目的比较大川芎口服液与通天口服液治疗中风恢复期的临床疗效、安全性和经济性。方法对大川芎口服液与通天口服液治疗中风恢复期进行Meta分析。建立决策树模型,从医疗系统角度对大川芎口服液与通天口服液治疗中风恢复期进行成本-效果分析,计算增量成本-效果比(ICER),并进行敏感性分析。效果参数为临床有效率来源于临床文献Meta分析,成本参数为药品治疗成本。结果Meta分析结果显示,与通天口服液相比,在临床有效率[OR(95%CI)=3.50(2.31,5.32)]、美国国立卫生研究院卒中量表(NIHSS)评分[MD(95%CI)=1.81(1.35,2.28)]、日常生活活动能力(ADL)评分[MD(95%CI)=9.96(7.86,12.06)]和中医证候总积分[MD(95%CI)=3.14(2.81,3.47)]方面,大川芎口服液均显著更优,且大川芎口服不良事件发生数少于通天口服液。成本-效果分析显示,与通天口服液相比,大川芎口服液治疗中风恢复期可提高12%的有效率,同时降低204.96元的治疗成本。单因素敏感性分析表明基础分析结果较稳健。结论大川芎口服液治疗中风恢复期的临床效果优于通天口服液,且安全性更高,经济性更佳。Objective To compare the clinical efficacy and economy of Dachuanxiong oral liquid and Tongtian oral liquid in the treatment of stroke recovery.Methods The meta-analysis of Dachuanxiong oral liquid and Tongtian oral liquid in the treatment of stroke recovery period was carried out.A decision tree model was established to conduct cost-effectiveness analysis of Dachuanxiong oral liquid and Tongtian Oral liquid in stroke recovery period from the perspective of medical system,and the incremental cost-effectiveness ratio(ICER)was calculated,and sensitivity analysis was carried out.The effect parameter was clinical effective rate from clinical literature meta-analysis,and the cost parameter was drug treatment cost.Results Meta analysis showed that compared with Tongtian oral liquid,Dachuanxiong oral liquid was significantly better in total effective rate[or(95%CI)=3.50(2.31,5.32)],National Institutes of Health Stroke Scale(NIHSS)neurological function evaluation[MD(95%CI)=1.81(1.35,2.28)],activity of daily living(ADL)score[MD(95%CI)=9.96(7.86,12.06)]and total TCM syndrome volume[MD(95%CI)=3.14(2.81,3.47)].The number of adverse events of Dachuanxiong oral liquid was lower than that of Tongtian oral liquid.Cost effectiveness analysis showed that compared with Tongtian oral liquid,Dachuanxiong oral liquid could improve the effective rate by 12%and reduce the treatment cost by 204.96 CNY.Single factor sensitivity analysis showed that the results of basic analysis were robust.Conclusion Dachuanxiong oral liquid is better than Tongtian oral liquid in the treatment of stroke recovery,and has better safety and economy.

关 键 词：大川芎口服液 通天口服液 中风恢复期 META分析 成本-效果分析 

分 类 号：R255.2[医药卫生—中医内科学] R956[医药卫生—中医学]