都梁软胶囊治疗偏头痛的药物经济学评价  

Pharmacoeconomic Evaluation of Duliang Soft Capsule in the Treatment of Migraine

作　　者：丁砚兵[1] 陈小敏[1] 郑波 郭蓉娟[3] DING Yan-Bing;CHEN Xiao-Min;ZHENG Bo;GUO Rong-Juan(Department of Encephalopathy,Hubei Hospital of Traditional Chinese Medicine,Wuhan 430061,China;Chongqing Rongchang District People's Hospital,Chongqing 402460,China;Department of Encephalopathy,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 102401,China)

机构地区：[1]湖北省中医院脑病科,武汉430061 [2]重庆市荣昌区人民医院,重庆402460 [3]北京中医药大学东方医院脑病科,北京102401

出　　处：《中国药物经济学》2025年第1期24-28,40,共6页China Journal of Pharmaceutical Economics

摘　　要：目的基于文献数据,评价都梁软胶囊治疗偏头痛的成本-效果。方法检索国内外权威数据库,收集都梁软胶囊治疗偏头痛的随机对照试验文献,纳入656例偏头痛患者,采用RevMan 5.3统计软件进行Meta分析。建立决策树模型,从医疗系统角度进行成本-效果分析。效果参数为临床总有效率,来源于临床文献Meta分析,成本参数为药品治疗成本,计算增量成本-效果比(ICER)并通过单因素敏感性分析检验基础分析结果的稳健性。结果Meta分析结果显示,都梁软胶囊联合基础西医用药的临床总有效率优于基础西医用药。成本-效果分析显示,疗程为2周时,都梁软胶囊+基础西医用药较基础西医用药治疗偏头痛的临床总有效率每增加1%,成本增加7.01元;疗程为2周以上时,都梁软胶囊+基础西医用药较基础西医用药治疗偏头痛的临床总有效率每增加1%,成本增加11.09元。在假定患者的意愿支付阈值为2023年人均可支配收入39218元的情况下,都梁软胶囊联合基础西医用药治疗比基础西医用药治疗更具经济性。结论都梁软胶囊联合基础西医用药相比于基础西医用药治疗偏头痛更具有成本-效果优势。Objective Based on literature data,the cost-effectiveness of Duliang soft capsule in the treatment of migraine was evaluated.Methods Authoritative databases at home and abroad were searched to collect randomized controlled trials of Duliang soft capsule in the treatment of migraine.A total of 656 patients with migraine were included.RevMan 5.3 was used for meta-analysis.A decision tree model was established to conduct cost-effectiveness analysis from the perspective of the medical system.The effect parameter was the total clinical efficacy,which was derived from the meta-analysis of clinical literature.The cost parameter was the cost of drug treatment.The incremental cost-effectiveness ratio(ICER)was calculated,and the stability of the basic analysis results was tested by univariate sensitivity analysis.Results The results of meta-analysis showed that Duliang soft capsule combined with basic Western medicine in the treatment of migraine had certain advantages over basic Western medicine in improving the total efficacy.The cost-effectiveness analysis showed that when the course of treatment was 2 weeks,the cost of Duliang soft capsule+basic Western medicine increased by 7.01 yuan for every 1%increase in the total clinical efficacy of migraine compared with basic Western medicine;when the course of treatment was more than 2 weeks,the cost of Duliang soft capsule+basic Western medicine increased by 11.09 yuan for every 1%increase in the total clinical efficacy of migraine compared with basic Western medicine.Under the assumption that patients'willingness to pay threshold is 39,218 yuan per capita disposable income in 2023,the treatment of Duliang soft Capsule combined with basic Western medicine is more economical than that of basic Western medicine.Conclusion Duliang soft Capsule combined with basic Western medicine has more cost-effectiveness advantages than basic Western medicine in the treatment of migraine.

关 键 词：都梁软胶囊 偏头痛 META分析 成本-效果分析 

分 类 号：R277.7[医药卫生—中医学] R956