汉防己甲素片联合乙酰半胱氨酸颗粒治疗尘肺的临床效果  

Clinical Efficacy of Hanfangjisu Tablets combined with Acetylcysteine Granules in the Treatment of Pneumoconiosis

作　　者：戴平[1] 刘悦梅 DAI Ping;LIU Yue-Mei(Shandong Institute of Occupational Health and Occupational Disease Prevention and Control,Jinan 250012,China;Medical Imaging Center of the Second Hospital of Shandong University,Jinan 250033,China)

机构地区：[1]山东省职业卫生与职业病防治研究院,济南250012 [2]山东大学第二医院医学影像中心,济南250033

出　　处：《中国药物经济学》2025年第1期81-83,87,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨汉防己甲素片联合乙酰半胱氨酸颗粒治疗尘肺的临床效果。方法选取2020年1月至2022年12月山东省职业卫生与职业病防治研究院收治的100例尘肺患者,随机分为对照组与试验组,各50例。两组均予以常规治疗,同时对照组予以乙酰半胱氨酸颗粒治疗,试验组采用汉防己甲素片联合乙酰半胱氨酸颗粒治疗。比较两组肺功能指标、炎症因子水平、症状评分、并发症发生率、治疗有效性、不良反应发生情况。结果治疗后,试验组第一秒钟用力呼气容积(FEV1)、用力肺活量(FVC)高于对照组(P<0.05);治疗后试验组C反应蛋白(CRP)、白细胞介素-6(IL-6)水平低于对照组(P<0.05);治疗后试验组咳嗽、咳痰、胸痛评分低于对照组(P<0.05);试验组并发症发生率低于对照组(P<0.05);试验组治疗有效率高于对照组(P<0.05);试验组不良反应发生率略低于对照组,但差异无统计学意义(P>0.05)。结论选取汉防己甲素片联合乙酰半胱氨酸颗粒治疗,可使尘肺患者的肺功能得到改善,降低炎症因子水平,减轻咳嗽症状,提高治疗效率,降低并发症发生率,且安全性较高。Objective To explore the clinical efficacy of Hanfangjisu tablets combined with acetylcysteine granules in the treatment of pneumoconiosis.Methods A total of 100 pneumoconiosis patients admitted to Shandong Institute of Occupational Health and Occupational Disease Prevention from January 2020 to December 2022 were randomly divided into control group and experimental group,with 50 cases in each group.Both groups were given conventional treatment,while the control group was treated with acetylcysteine granules,and the experimental group was treated with tetrandrine tablets combined with acetylcysteine granules.The pulmonary function index,inflammatory factor level,symptom score,complication rate,treatment effectiveness and adverse reactions were compared between the two groups.Results After treatment,forced expiratory volume(FEV1)and forced vital capacity(FVC)in the first second of experimental group were higher than those in control group(P<0.05).After treatment,the levels of C-reactive protein(CRP)and interleukin-6(IL-6)in experimental groups were lower than those in control group(P<0.05);After treatment,the scores of cough,expectoration and chest pain in experimental groups were lower than those in control group(P<0.05).The complication rate of experimental group was lower than that of control group(P<0.05).The effective rate of experimental group was higher than that of control group(P<0.05).The incidence of adverse reactions in experimental groups was slightly lower than that in control group,but the difference was not statistically significant(P>0.05).Conclusion Choosing hanfandrine tablets combined with acetylcysteine granules for treatment can improve the lung function of patients with pneumoconiosis,reduce the level of inflammatory factors,alleviate cough symptoms,improve treatment efficiency,reduce the incidence of complications,and have high safety.

关 键 词：汉防己甲素片 乙酰半胱氨酸颗粒 尘肺 肺功能 治疗有效性 

分 类 号：R563.9[医药卫生—呼吸系统] R974[医药卫生—内科学]