基于时间选通光子计数技术的共焦fNIRS成像系统(特邀)  

Confocal Functional Near-Infrared Spectroscopy Imaging System Using Time-Gated Photon-Counting Technology(Invited)

作　　者：李志勇 刘东远 高峰[1,2] Li Zhiyong;Liu Dongyuan;Gao Feng(College of Precision Instruments and Optoelectronics Engineering,Tianjin University,Tianjin 300072,China;Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments,Tianjin 300072,China)

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津市生物医学检测技术与仪器重点实验室,天津300072

出　　处：《光学学报(网络版)》2024年第5期11-17,共7页Acta Optica Sinica(Online)

基　　金：国家自然科学基金(81971656,62075156,62205239);中国博士后自然科学基金(2023M732600)

摘　　要：设计了一套基于时间选通光子计数技术的共焦型功能性近红外光谱(fNIRS)成像系统,在共焦阵列下以合理成本实现了高灵敏度和高空间分辨信息的可靠采集,并通过一系列的功能测试和仿体实验验证了系统的性能。功能测试结果表明,该系统可以10 ps的时间分辨率在0~10 ns范围内自由设置时间选通窗的位置和宽度;仿体实验结果表明,该系统在共焦阵列下的定量相对比提升超过32.9%,对比噪声比提升超过31.6%,空间保真度提升超过29.5%。可见,所设计的基于时间选通光子计数技术的共焦fNIRS成像系统以高性价比的方式有效提升了成像质量,为fNIRS的相关研究提供了仪器支撑和方法借鉴。We introduce a confocal functional near-infrared spectroscopy(fNIRS)imaging system that utilizes a time-gated photon-counting technology.This innovative approach enables the acquisition of high sensitivity and high spatial resolution information within a confocal array while considering cost-effectiveness.The performance of the system is confirmed through a series of functional tests and phantom experiments.Results from these tests show that the system can freely set the position and width of the time gating window within a range of 0 to 10 ns,with a temporal resolution of 10 ps.Phantom experiment results indicate that the system achieves a quantitative ratio improvement of over 32.9%in the confocal array,an enhancement of more than 31.6%in the contrast-to-noise ratio,and an increase of over 29.5%in spatial fidelity.Therefore,the confocal fNIRS imaging system designed in this study,using time-gated photon-counting technology,effectively improves imaging quality at a reasonable cost.This provides instrumental support and methodological reference for related fNIRS research.

关 键 词：功能性近红外光谱 共焦源探阵列 时间门控 光子计数 

分 类 号：O434[机械工程—光学工程]