微针递药系统在关节炎治疗中的研究进展  

Advances in Microneedle Drug Delivery Systems in the Treatment of Arthritis

作　　者：宋振洁 马银玲 董海鑫[1] 赵锋 潘振华 SONG Zhenjie;MA Yinling;DONG Haixin;ZHAO Feng;PAN Zhenhua(Dept.of Pharmaceutics,School of Pharmacy,Hebei Medical University,Shijiazhuang 050017;Dept.of Pharmacy,Hebei General Hospital,Shijiazhuang050051)

机构地区：[1]河北医科大学药学院药剂学教研室,河北石家庄050017 [2]河北省人民医院药学部,河北石家庄050051

出　　处：《中国医药工业杂志》2025年第2期155-162,共8页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(82104286);河北省自然科学基金项目(H2021206275、H2020307043);河北医科大学大学生创新性实验计划项目(USIP2023041、USIP2023086)。

摘　　要：关节炎的治疗多采用长期口服或关节腔内注射非甾体抗炎药来减轻炎症反应、延缓病情发展,但会导致胃肠道刺激性、肝毒性及关节内感染等不良反应。微针作为一种经皮给药剂型,可穿过角质层屏障,将药物递送至免疫细胞丰富的表皮深处和真皮层,凭借其微创、提高药物渗透性等优势在关节炎治疗领域得到了广泛的关注与应用。该文介绍了微针在治疗关节炎疾病方面的进展,以期为关节炎的制剂研发提供参考。The treatment for arthritis often involves long-term oral administration or intra-articular injection of nonsteroidal anti-inflammatory drugs to alleviate inflammation and slow down the progression of the disease.However,these treatments may give rise to gastrointestinal irritation,hepatotoxicity,intra-articular infections,and other adverseeffects.As a transdermal drug delivery system,microneedles can penetrate the stratum corneum barrier to deliver drugs to the deeper epidermis and dermis layer rich in immune cells,and has attracted widespread attention and application in the field of arthritis treatment due to its advantages of minimally invasive and improved drug permeability.This review elaborates on the progress of microneedles in the treatment of arthritis,in order to provide a reference for the development of preparations for arthritis treatment.

关 键 词：微针 经皮递药系统 可溶性微针 水凝胶微针 类风湿性关节炎 骨关节炎 痛风性关节炎 研究进展 

分 类 号：R943[医药卫生—药剂学] R944.9[医药卫生—药学]