铝佐剂研究进展  

Research Progress of Aluminum-containing Adjuvants

作　　者：张冉 闫向波 石献华 ZHANG Ran;YAN Xiangbo;SHI Xianhua(Production Center,Beijing Zhifei Lvzhu Biopharmaceutical Co.,Ltd.,Beijing 100176)

机构地区：[1]北京智飞绿竹生物制药有限公司生产中心,北京100176

出　　处：《中国医药工业杂志》2025年第2期163-169,共7页Chinese Journal of Pharmaceuticals

摘　　要：铝佐剂具有高安全性、耐受性和成本低等优点,是疫苗佐剂的首选方案。但是,目前铝佐剂促进机体免疫的具体机制仍不明确。文章总结了铝佐剂的特点、不同铝佐剂的差异和应用,整理了近些年来关于铝佐剂如何促进机体免疫反应的各种机制研究,以帮助研究者深入了解铝佐剂,为新型佐剂的开发提供参考。Aluminum-containing adjuvants have the advantages of high safety,tolerance,and low cost,making them the preferred option for vaccine adjuvants.However,the mechanism of aluminum-containing adjuvants to elicit the immune system remains elusive.The article summarizes the characteristics of aluminum-containing adjuvants,the differencesand applications of various aluminum-containing adjuvants,and organizes various mechanisms research on howaluminum-containing adjuvants promote immune responses in recent years,providing a deeper understanding ofaluminum-containing adjuvants and offering references for the development of new adjuvants.

关 键 词：铝佐剂 疫苗 免疫 研究进展 

分 类 号：R186[医药卫生—流行病学]