吲哚类物质在生殖领域的研究进展  

Research progress of indoles in reproduction system

作　　者：郑建秀 刘阿慧 王丽艳[2] 金盼盼 高嘉伟 张学红[2] ZHENG Jian-xiu;LIU A-hui;WANG Li-yan;JIN Pan-pan;GAO Jia-wei;ZHANG Xue-hong(The First Clinical Medical College of Lanzhou University,Lanzhou 730000;The First Hospital of Lanzhou University,Lanzhou 730000)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院,兰州730000

出　　处：《生殖医学杂志》2025年第3期416-420,共5页Journal of Reproductive Medicine

基　　金：兰州大学第一医院院内基金(ldyyyn2022-20)。

摘　　要：越来越多的证据表明,肠道微生物及其代谢产物在不同人对疾病易感性以及对饮食的反应中起重要作用。肠道微生物代谢色氨酸产生的吲哚类物质可作为一种信号分子发挥作用,这种代谢物通过与芳基烃受体结合来影响免疫稳态,同时在体循环中具有抗炎、抗氧化及抗肿瘤等特性,并反过来影响肠道微生物的组成结构。近年来,人们对这些肠道微生物衍生的吲哚代谢物在生殖系统疾病中的关注度逐渐加大。因此,本文就吲哚类物质在生殖系统相关方面的研究进展进行综述。There is growing evidence that gut microbes and their metabolites play an important role in disease susceptibility and response to diet in different individuals.Indoles produced by gut microbes metabolizing tryptophan can function as a signaling molecule,and this metabolite influences immune homeostasis by binding to aromatic hydrocarbon receptors,as well as possesses anti-inflammatory,antioxidant,and antitumor properties in the somatic circulation and,in turn,influences the compositional structure of gut microbes.In recent years,there has been a growing interest in these gut microbe-derived indole metabolites in reproductive disorders.Therefore,this article provides a review of the progress of research on indole analogs related to the reproductive system.

关 键 词：肠道微生物 色氨酸代谢 吲哚 生殖系统 

分 类 号：R711[医药卫生—妇产科学]