谷氨酸在肠道内的功能及其转运机制的研究进展  

Research progress on the intestinal function and transport mechanism of glutamate

作　　者：王敏之 吴苏君 马驰骋 宋菲菲 李希 王宏浩 王曦[1] Wang Minzhi;Wu Sujun;Ma Chicheng;Song Feifei;Li Xi;Wang Honghao;Wang Xi(College of Animal Science,Shanxi Agricultural University,Shanxi Jinzhong 030801)

机构地区：[1]山西农业大学动物科学学院,山西晋中030801

出　　处：《现代畜牧兽医》2025年第1期91-96,共6页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：山西省青年科学基金项目(20210302124640);山西省科技重大专项计划(202201140601026-1);山西省自然科学基金项目(201901D221132);山西农业大学生物育种工程(YZGC131)。

摘　　要：谷氨酸作为哺乳动物肠上皮细胞的主要氧化燃料,是肠道内合成生物活性物质的特定前体,对动物肠道健康发育具有重要意义。文章主要综述了谷氨酸在肠道内参与氨基酸代谢、肠黏膜免疫和发挥神经递质作用等3个方面的功能,重点讨论了谷氨酸转运蛋白在肠上皮细胞内的表达,探索谷氨酸在机体内可能存在的运转调控机制,以期为谷氨酸的科学应用以及治疗动物肠道疾病提供参考。Glutamate,as the primary oxidative fuel for mammalian intestinal epithelial cells,is a specific precursor for the synthesis of bioactive substances within the intestine and plays a significant role in the healthy development of animal intestinal tracts.This article mainly reviewed the functions of glutamate in the intestinal tract,including its participation in amino acid metabolism,intestinal mucosal immunity and neurotransmitter function.The expression of glutamate transporter in intestinal epithelial cells was mainly discussed,and the possible regulatory mechanism of glutamate in the body was explored,with a view to providing references for the scientific application of glutamate and the treatment of animal intestinal diseases.

关 键 词：谷氨酸 肠上皮细胞 谷氨酸转运蛋白 吸收运转 

分 类 号：S852[农业科学—基础兽医学]