壳聚糖/海藻酸钙止血海绵的制备与性能  

Preparation and properties of a chitosan/calcium alginate hemostatic sponge

作　　者：罗爽 巫瑛 李慧敏 苏静 王鸿博 LUO Shuang;WU Ying;LI Huimin;SU Jing;WANG Hongbo(College of Textile Science and Engineering,Jiangnan University,Wuxi 214122,China;Sheng Huadun Protection Technology Co.,Ltd.,Wuxi 214413,China)

机构地区：[1]江南大学纺织科学与工程学院,江苏无锡214122 [2]圣华盾防护科技股份有限公司,江苏无锡214413

出　　处：《现代纺织技术》2025年第3期8-15,共8页Advanced Textile Technology

基　　金：国家自然科学基金项目(52003108)。

摘　　要：为解决传统海藻酸钙止血海绵工艺复杂、耗时过长的问题,以壳聚糖、碳酸钙、海藻酸钠和甘油为原料,通过离子交联、内凝胶法经一步冷冻干燥工艺得到具有多孔结构的止血海绵,并通过吸液率测试、保水率测试、水蒸气透过率测试和电子万能拉力机测试分析CaCO_(3)含量对壳聚糖/海藻酸钙海绵吸液性能、力学性能、透气性能和保水性能的影响,同时探讨了Ca^(2+)的释放促进机体自身的凝血机制。结果表明:该海绵的溶血率在2%以下,凝血指数可达到13%左右,具有较好凝血效果和生物相容性,在止血海绵敷料方面有很大应用前景。In daily life as well as in clinical surgery,the first problem that needs to be solved is how to quickly stop bleeding from wounds.Prolonged exposure of wounds to air can easily lead to infections and loss of bodily fluids,which can impact wound healing and,in severe cases,even cause complications.This can impact wound healing and,in severe cases,even lead to complications.Traditional dressings are still widely used on skin injuries,primarily due to their affordability,simplicity in preparation,and ease of application.However,their role in wound healing is limited by their simple physical coverage,tendency to adhere to wounds and limited capacity to absorb tissue fluid,which restricts their effectiveness in wound healing.Natural polysaccharides are highly advantageous in the direction of preparing new sponge dressings due to their excellent biocompatibility,degradability,widespread availability,and affordability.Sponge dressings made from polysaccharides not only retain the sponge's excellent breathability and fluid absorption capabilities but also possess the inherent advantages of polysaccharides.Calcium carbonate(CaCO_(3))is an inorganic material widely found in natural substances such as limestone and coral,which is inexpensive,readily available,safe and non-toxic,and therefore has garnered significant attention in the biomedical industry.To improve the sponge formed by the exogenous gel method of freeze-drying traditional calcium alginate sponges,it is necessary to address issues such as hard texture,lengthy process,and uneven cross-linking.One way to achieve this is by re-crosslinking the sponge through immersion in calcium chloride solution.The thesis uses sodium alginate(SA)and chitosan(CS)as the base materials,CaCO_(3) as the source of Ca^(2+) for ionic cross-linking,and regulates the pH value of the solvent to control the cross-linking speed to simultaneously trigger ionic cross-linking and electrostatic interactions,and employs internal gelation to stabilize the sponge's cross-linked structure,so that

关 键 词：碳酸钙 壳聚糖 海藻酸钠 止血海绵 体外凝血 液体吸收 

分 类 号：TS102.5[轻工技术与工程—纺织工程]