基于“肠-肺”轴探讨中医药调控肠道菌群抗甲型流感病毒感染作用机制  

Exploring Mechanism of Chinese Medicine in Regulating Gut Microbiota Against Influenza A Virus Infection Based on"Gut-Lung"Axis

作　　者：郭紫薇 汪九重 黄渤皓 李彦波 吴东杰 吕文良[1] GUO Zi-wei;WANG Jiu-chong;HUANG Bo-hao;LI Yan-bo;WU Dong-jie;LU Wen-liang(Department of Infectious Diseases,Guang'anmen Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100053;Graduate School,Beijing University of Chinese Medicine,Beijing 100105)

机构地区：[1]中国中医科学院广安门医院感染疾病科,北京100053 [2]北京中医药大学研究生院,北京100105

出　　处：《中国中西医结合杂志》2025年第2期229-234,共6页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：中央高水平中医医院临床研究和成果转化能力提升项目-中医药临床循证研究专项(No.HLCMHPP20230)。

摘　　要：甲型流感病毒(IAV)是一种常见的呼吸道病原体,可引起季节性流感,并在某些情况下导致全球大流行,对全球公共卫生构成重大威胁。研究表明,IAV感染可能会打破肠道微生物群的平衡,从而影响IAV患者病情的发展。因此,恢复肠道微生物群的平衡可能成为治疗IAV感染的潜在靶点之一。中药能够调节肠道微生物群,并在预防和治疗IAV方面展现出巨大的潜力。本文基于“肠-肺”轴,探讨中医药通过调节黏膜屏障功能、免疫和炎症反应,以及代谢产物平衡等途径,调控肠道菌群抗IAV感染的多靶点、多层次作用机制,以期为临床治疗甲型流感提供新途径和新思路。Influenza A viruses(IAV)is a common respiratory pathogens that cause seasonal influenza and global pandemics, posing significant challenges to public health. Recent researches demonstrated that IAV infection disrupts the homeostasis of the gut microbiota, thereby influencing disease progression in infected individuals. Consequently, restoring gut microbiota balance may offer a promising therapeutic strategy for IAV infection. Chinese medicine(CM)has shown considerable potential in modulating the gut microbiota and in both preventing and treating IAV. This article explores the multi-target and multi-level mechanisms by which CM regulates the gut microbiota in combating IAV infection, focusing on its effects on mucosal barrier function, immune and inflammatory responses, and metabolite homeostasis. The goal is to provide novel approaches and insights for the clinical management of IAV.

关 键 词：肠道微生物 肠道菌群 肠-肺轴 甲型流感病毒感染 中医药 免疫应答 

分 类 号：S85[农业科学—兽医学]