补阳还五汤加味联合沙库巴曲缬沙坦治疗慢性心力衰竭的效果  

Effect of modified Buyang Huanwu decoction combined with sacubitril valsartan on chronic heart failure

作　　者：李晓贝 侯美伶 王庆凯[1] 冀晓薇 LI Xiaobei;HOU Meiling;WANG Qingkai;JI Xiaowei(Department of Cardiology,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou O61000,Hebei Province,China;Department of Emergency,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,Hebei Province,China;Department of Cardiology,Raoyang County Traditional Chinese Medicine Hospital,Hengshui 053900,Hebei Province,China)

机构地区：[1]河北省沧州中西医结合医院心内科,河北沧州061000 [2]河北省沧州中西医结合医院急诊科,河北沧州061000 [3]饶阳县中医医院心内科,河北衡水053900

出　　处：《世界临床药物》2025年第1期44-49,共6页World Clinical Drug

基　　金：河北省中医药管理局科研计划项目(2020544)。

摘　　要：目的观察补阳还五汤加味联合沙库巴曲缬沙坦对慢性心力衰竭(chronic cardiac failure,CHF)的疗效。方法选取沧州中西医结合医院2021年11月至2023年6月收治的证属气虚血瘀的120例CHF患者,随机分为西药组(n=60)和中西药联合组(n=60)。西药组在常规治疗基础上给予沙库巴曲缬沙坦治疗,中西药联合组在西药组基础上加服补阳还五汤加味,疗程3个月。结果治疗后两组中医证候积分、生活质量评分、氨基末端脑钠肽前体、心肌肌钙蛋白T水平和左心室心肌质量指数较治疗前降低(P<0.05),左心室射血分数和6 min步行试验较治疗前升高(P<0.05),且中西药联合组上述指标均优于西药组(P<0.05)。中西药联合组治疗总有效率显著高于西药组(91.67%vs 76.67%,P<0.05)。中西药联合组与西药组不良反应发生率比较,差异无统计学意义(8.33%vs 13.33%,P>0.05)。结论补阳还五汤加味联合沙库巴曲缬沙坦对CHF疗效较高,能改善患者心功能及生活质量。Objective To observe the effect of modified Buyang Huanwu decoction combined with sacubitril valsartan on chronic cardiac failure(CHF).Methods A total of 120 CHF patients with Qi deficiency and blood stasis admitted to Cangzhou Integrated Traditional Chinese and Western Medicine Hospital from November 2021 to June 2023 were randomly divided into western medicine group(n=60)and Chinese and western medicine combined group(n=60).The western medicine group was treated with sacubitril valsartan on the basis of conventional treatment,and the Chinese and western medicine combined group was treated with modified Buyang Huanwu decoction on the basis of western medicine group,with a course of 3 months.Results After treatment,the traditional Chinese medicine syndrome score,quality of life score,N-terminal brain natriuretic peptide precursor,myocardial troponin T level and left ventricular mass index in the two groups were decreased compared with before treatment(P<0.05),the left ventricular ejection fraction and 6 min walking test were higher than those before treatment(P<0.05),and the above indexes in Chinese and western medicine combined group were better than those in western medicine group(P<0.05).The total effective rate of the combined group was obviously higher than that of the western medicine group(91.67%vs 76.67%,P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group and western medicine group(8.33%vs 13.33%,P>0.05).Conclusion Modified Buyang Huanwu decoction combined with sacubitril valsartan has high curative effect on CHF,and can improve the heart function and quality of life of patients.

关 键 词：慢性心力衰竭 补阳还五汤加味 沙库巴曲缬沙坦 

分 类 号：R972.1[医药卫生—药品] R541.6[医药卫生—药学] R287