抗菌肽作用机制及应用研究进展  

Research progress of mechanisms and application of antimicrobial peptides

作　　者：高杰 邓轶方 刘珉宇 GAO Jie;DENG Yifang;LIU Minyu(State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437,China;Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437,China)

机构地区：[1]中国医药工业研究总院创新药物与制药工艺国家重点实验室,上海200437 [2]上海市生物物质成药性评价技术服务平台,上海200437

出　　处：《世界临床药物》2025年第1期66-72,共7页World Clinical Drug

基　　金：先导物成药性研究与药物平台开发建设(23002400100)。

摘　　要：随着抗菌药物的广泛使用,微生物耐药性的不断发展对全球健康构成重大威胁。因此,寻找新型抗菌药物或其他抗菌资源成为全球科学研究的重点。抗菌肽(antimicrobial peptides,AMPs)作为克服抗菌药物耐药性的优秀候选者,获得广泛关注。AMPs是一类由生物体自然产生的小分子蛋白,在宿主针对多种微生物(包括细菌、真菌和病毒等)的先天免疫中发挥至关重要的作用。AMPs广泛存在于微生物、植物、昆虫和哺乳动物等各种生物体内。AMPs通过靶向细胞膜、细胞壁、细胞内的DNA和蛋白质等关键分子发挥生物活性。广泛的来源和复杂多样的作用机制为AMPs的广泛应用提供坚实的基础。该文综述AMPs基于动物来源的分类、作用机制及其在医药领域的应用现状,旨在为相关领域的进一步研究提供参考。With the widespread use of antibiotics,the ongoing development of microbial resistance poses a significant threat to global health.Therefore,the search for new antibiotics or other antimicrobial resources has become the focus of global scientific research.Antimicrobial peptides(AMPs)have attracted much attention as excellent candidates for overcoming antibiotic resistance.AMPs are small molecular proteins that are naturally produced by all living organisms and play a crucial role in the host's innate immunity against a variety of microorganisms,including bacteria,fungi,and viruses.AMPs are widely found in various organisms such as microorganisms,plants,insects,and mammals.AMPs exert biological activity by targeting key molecules such as cell membranes,cell walls,DNA and proteins within cells.The wide range of sources and complex and diverse mechanisms provide a solid foundation for the wide application of AMPs.This article reviewed the classification of AMPs based on animal origin,the mechanisms and applications in pharmaceutical field,in order to provide professional reference for further research in related fields.

关 键 词：抗菌肽 动物抗菌肽 作用机制 

分 类 号：R978[医药卫生—药品]