温振运气方对脾肾阳虚型慢性疲劳综合征患者的免疫调节作用  

Immunomodulatory effect of Wenzhen Yunqi Formula in patients with chronic fatigue syndrome of spleen and kidney yang deficiency type

作　　者：葛文金 崔孔蛟 唐暐[2] 潘泗红 张振贤[1] 史佳宁[1] GE Wenjin;CUI Kongjiao;TANG Wei;PAN Sihong;ZHANG Zhenxian;SHI Jianing(Department of Traditional Chinese Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院中医内科,上海200437 [2]上海交通大学医学院附属瑞金医院,上海200025

出　　处：《上海中医药大学学报》2025年第1期80-86,共7页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海中医药大学附属岳阳中西医结合医院优势专科建设项目[YW(2023-2024)-01-07];上海中医药大学附属岳阳中西医结合医院名医工作室建设项目。

摘　　要：目的:观察温振运气方对脾肾阳虚型慢性疲劳综合征(CFS)患者的免疫调节作用。方法:采用随机双盲对照的研究方法,将纳入的82例脾肾阳虚型CFS患者分为试验组和对照组,每组各41例。试验组患者予以温振运气方颗粒剂治疗,对照组患者予以安慰剂治疗,两组疗程均为8周。治疗前后比较两组患者的疲劳量表-14(FS-14)、疲劳评定量表(FAI)、疲劳症状量表评分及中医证候主症评分、总积分;治疗后,评价并比较两组患者的中医证候疗效;治疗前后检测并比较两组患者的外周血T细胞、B细胞、自然杀伤(NK)细胞、CD4^(+)T细胞、CD8^(+)T细胞水平及CD4^(+)/CD8^(+)值;治疗前后检测并比较两组患者的外周血免疫球蛋白(Ig)G、IgA、IgM水平。结果:研究期间,对照组1例患者脱落,最终纳入统计分析者试验组41例、对照组40例。①治疗后,试验组患者的FS-14、FAI、疲劳症状量表评分较治疗前均降低(P<0.05),且低于对照组(P<0.05);而对照组患者的上述评分治疗前后比较,差异均无统计学意义(P>0.05)。②治疗后,试验组患者的主症评分及中医证候总积分较治疗前均降低(P<0.05),且低于对照组(P<0.05);而对照组患者的上述评分治疗前后比较,差异均无统计学意义(P>0.05)。③治疗后,试验组的中医证候疗效总有效率为87.8%,对照组为35.0%,试验组的疗效优于对照组(P<0.05)。④治疗后,试验组患者的T细胞、NK细胞、CD4^(+)T细胞水平及CD4^(+)/CD8^(+)值较治疗前均升高,CD8^(+)T细胞水平降低(P<0.05),且试验组患者的T细胞、NK细胞、CD4^(+)T细胞水平及CD4^(+)/CD8^(+)值高于对照组,CD8^(+)T细胞水平低于对照组(P<0.05);而对照组患者的各项淋巴细胞水平治疗前后比较,差异均无统计学意义(P>0.05)。⑤治疗后,试验组患者的IgG水平较治疗前升高(P<0.05),且高于对照组(P<0.05);而对照组患者的各项Ig水平治疗前后比较,差异均无统计学意义(P>0.05)。�Objective:To observe the immunomodulatory effect of Wenzhen Yunqi Formula in patients with chronic fatigue syndrome(CFS)of spleen and kidney yang deficiency type.Methods:A randomized,double-blind,controlled study approach was used.Eighty-two patients with CFS of spleen and kidney yang deficiency type were divided into the experimental group and control group,41 cases in each group.The patients in the experimental group were treated with Wenzhen Yunqi Formula granules,and the patients in the control group were treated with placebo,with a course of 8 weeks.Before and after treatment,the scores of Fatigue Scale-14(FS-14),Fatigue Assessment Instrument(FAI),Fatigue Symptom Scale,and the main symptom scores and total score of Chinese medical syndrome were compared between the two groups.After treatment,the efficacy of Chinese medical syndrome was evaluated and compared between the two groups.Before and after treatment,the levels of T lymphocyte,B lymphocyte,nature killer(NK)cell,CD4^(+)T cell,CD8^(+)T cell in peripheral blood and CD4^(+)/CD8^(+)value were detected and compared between the two groups.Before and after treatment,the levels of immunoglobulin(Ig)G,IgA and IgM in peripheral blood were detected and compared between the two groups.Results:During the research,1 case in the control group was shed off,finally 41 cases in the experimental group and 40 cases in the control group were included in the statistical analysis.①After treatment,the scores of FS-14,FAI,and Fatigue Symptom Scale in the experimental group were decreased compared with those before treatment(P<0.05),and were lower than those in the control group(P<0.05).While there were no statistically significant differences on above scores in the control group between before and after treatment(P>0.05).②After treatment,the main symptom scores and the total score of Chinese medical syndrome in the experimental group were decreased compared with those before treatment(P<0.05),and were lower than those in the control group(P<0.05).While there were no statis

关 键 词：慢性疲劳综合征 温振运气方 免疫调节 细胞免疫 体液免疫 中医药疗法 

分 类 号：R259[医药卫生—中西医结合]