基于ICP-MS测定硼中子俘获治疗中全血硼浓度的方法探究  

Study on Determination of Boron Concentration in Human Blood for Boron Neutron Capture Therapy by Indictive Coupled Plasma Mass Spectrometry

作　　者：傅霜 孙晓萍 卞亚 陈腊梅 周平 FU Shuang;SUN Xiao-ping;BIAN Ya;CHEN La-mei;ZHOU Ping(Xiamen Laboratory,Neuboron Bio-SciTech Co.,Ltd.,Xiamen 361000,China)

机构地区：[1]中硼(厦门)生物医药有限公司厦门实验室,福建厦门361000

出　　处：《分析测试学报》2025年第3期540-543,共4页Journal of Instrumental Analysis

基　　金：国家重点研发计划政府间国际科技创新合作重点项目中日项目(2022YFE0107800)。

摘　　要：该文基于电感耦合等离子体质谱(ICP-MS)技术建立了一套人体全血硼浓度的检测方法,该方法采用0.1%硝酸和0.1%Triton X-100的混合溶液直接稀释全血样品,并验证了方法的系统适用性、定量范围、精密度和准确度、基质效应等。结果表明,在^(10)B为2~50μg/mL的定量范围内,方法的精密度和准确度良好且无基质效应。该方法具有操作简便、检测快速、数据可取用等特点,适用于硼中子俘获治疗(BNCT)期间患者血液中^(10)B浓度的实时监测。In this paper,based on inductively coupled plasma mass spectrometry(ICP-MS)technology,a method for measuring the boron concentration in human whole blood was established.Whole blood samples were diluted directly with a mixture solution of 0.1%nitric acid and 0.1%Triton X-100,and the system applicability,quantitative range,precision and accuracy,matrix effect and so on of the method were verified.The results showed that the method has the quantitative range of 2-50μg/mL for ^(10)B and has good precision and accuracy and no matrix effect.This method has the characteristics of easy operation,rapid detection and usable data,and is suitable for real-time monitoring of ^(10)B concentration in blood of patients during BNCT treatment.

关 键 词：ICP-MS 血硼浓度 硼中子俘获治疗(BNCT) 临床 

分 类 号：O657.6[理学—分析化学] R331.1[理学—化学]