线粒体质量控制在骨关节炎中的作用机制及应用前景  

The mechanism and application prospects of mitochondrial quality control in osteoarthritis

作　　者：王亮 邓银栓 屈涛 达朝明 贺云飞 刘锐 牛伟民 颜维舜 陈真 李硕 杨志云 郭斌斌 赖学倩 WANG Liang;DENG Yinshuan;QU Tao;DA Chaoming;HE Yunfei;LIU Rui;NIU Weimin;YANWeishun;CHEN Zhen;LI Shuo;YANG Zhiyun;GUO Binbin;LAI Xueqian(Orthopedics Department of Gansu Provincial Central Hospital,Lanzhou 730070,Gansu,China;Gansu Provincial Central Hospital,Lanzhou 730070,Gansu,China)

机构地区：[1]甘肃省中心医院骨科,甘肃兰州730070 [2]甘肃省中心医院,甘肃兰州730070

出　　处：《中国临床药理学与治疗学》2025年第2期282-288,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：兰州市科技计划项目资助(2022-ZD-64)。

摘　　要：骨关节炎(osteoarthritis,OA)是临床上常见的关节疾患,软骨损伤是其典型的病理改变。OA发病机制复杂,多种不良因素均可导致OA的发生。线粒体是细胞内重要的细胞器,在细胞生理病理活动中起重要作用。线粒体质量控制是机体为维持线粒体结构及功能正常的一种重要调控机制,主要包括线粒体生物发生、线粒体动力学、线粒体自噬、线粒体氧化应激等形式。软骨细胞线粒体质量控制失衡与OA的发生发展密切相关,调控线粒体质量控制的平衡是OA的潜在治疗点。笔者查阅近几年相关研究文献,就线粒体质量控制与OA发生发展的关系展开综述,以期为OA的发病机制研究及诊治策略提供新的思路和方向。Osteoarthritis(OA)is a common joint disease in clinical practice,and cartilage damage is a typical pathological change.The pathogenesis of OA is complex,and various adverse factors can lead to the occurrence of OA.Mitochondria are important organelles within cells and play important roles in cellular physiological and pathological activities.Mitochondrial quality control is an important regulatory mechanism in the body to maintain normal mitochondrial structure and function,mainly including mitochondrial biogenesis,mitochondrial dynamics,mitochondrial autophagy,mitochondrial oxidative stress,and other forms.The imbalance of mitochondrial quality control in chondrocytes is closely related to the occurrence and development of osteoarthritis,and regulating the balance of mitochondrial quality control is a potential therapeutic point for osteoarthritis.The author reviewed relevant research literature in recent years to provide a review of the relationship between mitochondrial quality control and the occurrence and development of osteoarthritis,in order to provide new ideas and directions for the research and diagnosis and treatment strategies of osteoarthritis.

关 键 词：骨关节炎 线粒体 机制 综述 

分 类 号：R684[医药卫生—骨科学]