原发性肺冲击伤相关信号通路研究进展  

Signaling pathways related to primary blast lung injury:research progress

作　　者：赵松韵 刁朝玥 白冲[1] ZHAO Songyun;DIAO Chaoyue;BAI Chong(Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200433,China;Department of Internal Medicine(Ⅰ),The Second Naval Hospital of PLA Southern Theater Command,Sanya 572000,Hainan,China;Department of Endocrinology,No.971 Hospital of PLA Navy,Qingdao 266000,Shandong,China)

机构地区：[1]海军军医大学(第二军医大学)第一附属医院呼吸与危重症医学科,上海200433 [2]中国人民解放军南部战区海军第二医院内一科,三亚572000 [3]中国人民解放军海军第九七一医院内分泌科,青岛266000

出　　处：《海军军医大学学报》2025年第3期406-410,共5页Academic Journal of Naval Medical University

基　　金：海南省自然科学基金(824QN408)。

摘　　要：原发性肺冲击伤是爆炸产生冲击波直接作用于肺脏导致的急性肺损伤,严重者可发展为急性呼吸窘迫综合征,是导致作业人员死亡的重要原因之一。原发性肺冲击伤的病理生理特征相对明确,病理上主要表现为肺泡-毛细血管损伤和随之而来的肺出血、肺水肿,伴随氧化应激、细胞凋亡、炎症反应等生理过程,但分子机制有待进一步研究。本文就近年来原发性肺冲击伤中PI3K/Akt、NF-κB、MAPK等信号通路的研究进展进行综述。Primary blast lung injury is an acute lung injury caused by the direct impact of explosive shock wave acting on the lung;the serious case can develop acute respiratory distress syndrome,which is one of the leading causes of mortality in blast injury personnel.The pathophysiological characteristics of primary lung blast injury are relatively clear:rupture of the alveolar capillaries and subsequent intrapulmonary haemorrhage and edema,accompanied by oxidative stress,apoptosis,inflammatory reaction and other physiological processes.However,the molecular mechanism needs to be further studied.This paper focuses on the research progress of phosphatidylinositol 3-kinase/protein kinase,nuclear factorκB,mitogen-activated protein kinase and other signaling pathways in the research of primary blast lung injury.

关 键 词：冲击伤 肺损伤 信号通路 磷酸肌醇3-激酶类 核因子ΚB 丝裂原活化蛋白激酶 

分 类 号：R655.3[医药卫生—外科学]