HBx调节lncRNA在HCC发生、发展中的研究进展  

Research progress on the regulation of HBx on lncRNA in the development of HCC

作　　者：田旭云 刘琳 曾怡 罗昊翔[1,2,3] TIAN Xu-yun;LIU Lin;ZENG Yi;LUO Hao-xiang(Department of Pathogenic Microbiology and Immunology,School of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise 533000,China;Guangxi Colleges and Universities Key Laboratory of Basic Research and Transformation of Tumor Immunity and Infectious Diseases,Baise 533000,China;Key Laboratory of Tumor Immunopathology,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院基础医学院病原微生物学与免疫学教研室,百色533000 [2]广西高校肿瘤免疫与感染性疾病基础研究与转化重点实验室,百色533000 [3]右江民族医学院肿瘤免疫病理学重点实验室,百色533000

出　　处：《现代免疫学》2025年第1期82-88,共7页Current Immunology

基　　金：广西自然科学技术基金项目(2018GXNSFAA138030);百色市科学研究与技术开发计划项目(百科20224133);右江民族医学院研究生创新计划项目(YXCXJH2023002)。

摘　　要：原发性肝细胞癌(hepatocellular carcinoma,HCC)是目前常见的恶性肿瘤之一,引发HCC的主要危险因素是HBV感染。乙型肝炎病毒X蛋白(hepatitis B virus X protein,HBx)是HBV相关肝细胞癌的关键调节因子,能够促进癌症的发生。许多长链非编码RNA(long non-coding RNA,lncRNA)能够导致HCC的发生,它们的主要功能包括促进HBV复制、上调癌基因或下调肿瘤抑制因子的表达,有些lncRNA还可以直接作为肿瘤抑制因子发挥作用,目前它们已经作为疾病治疗靶点被大量研究。该文将讨论经HBx调节的lncRNA在HBV诱导的HCC中的作用,并对肿瘤发生、发展的机制展开综述。Hepatocellular carcinoma (HCC) is one of the most common malignancies, and the main risk factor for HCC is HBV infection. Hepatitis B virus X protein (HBx) is a key regulator of HBV-associated HCC and can promote tumorigenesis. It has been reported that many long non-coding RNA (lncRNA) contribute to the HCC development, mainly by promoting HBV replication, up-regulating oncogenes expression, or down-regulating the expression of tumor suppressors.Some lncRNA can also act directly as tumor suppressors, which have been extensively studied as disease-treating targets.In this review, we will discuss the role of HBx-regulated lncRNA in HBV-induced HCC and summarize the mechanisms of tumorigenesis and the development of cancer.

关 键 词：原发性肝细胞癌 长链非编码核糖核酸 乙型肝炎病毒 乙型肝炎病毒X蛋白 

分 类 号：R392.11[医药卫生—免疫学]