N-苯基邻苯二甲酰亚胺的合成  

STUDY ON THE SYNTHESIS OF N-PHENYLPHTHALIMIDE

作　　者：南沛然 王博闻 李世云 文彬 陈兴权 鲍晓军[1,2] Nan Peiran;Wang Bowen;Li Shiyun;Wen Bin;Chen Xingquan;Bao Xiaojun(College of Chemical Engineering,Fuzhou University,Fuzhou 350000,Fujian,China;Qingyuan Innovation Laboratory,Quanzhou 362000,Fujian,China)

机构地区：[1]福州大学化工学院,福建福州350000 [2]清源创新实验室,福建泉州362000

出　　处：《精细石油化工》2025年第2期48-51,共4页Speciality Petrochemicals

基　　金：清源创新实验室项目基金(00522011)。

摘　　要：以苯胺和N-羟基邻苯二甲酰亚胺(NHPI)为原料,经缩合偶联反应得到N-苯基邻苯二甲酰亚胺,产物经核磁共振氢谱确证。缩合偶联反应的优化条件为:以2,2′-联吡啶为助催化剂,氯化亚铜(CuCl)为催化剂,物料比n(2,2′-联吡啶)∶n(氯化亚铜)∶n(苯胺)∶n(N-羟基邻苯二甲酰亚胺)=0.1∶0.2∶1.0∶1.0,乙腈为溶剂、温度为70℃、反应时间为4 h,反应气体环境为氧气,产物收率达82.0%。Using aniline and N-hydroxyphthalimide(NHPI)as raw materials,N-phenylphthalimide was obtained through condensation coupling reaction,and the product was confirmed by 1H NMR.The optimized conditions for the condensation coupling reaction are:2,2′-bipyridine(2,2′-bpy)as a co-catalyst,cuprous chloride(CuCl)as a catalyst,and a material ratio of n(2,2′-bipyridine)∶n(cuprous chloride)∶n(aniline)∶n(N-hydroxyphthalimide)=0.1∶0.2∶1.0∶1.0,acetonitrile as solvent,temperature of 70℃,the reaction time of 4 h,reaction in oxygen environment.Under optimized conditions,the yield of the reaction product reaches 82.0%.

关 键 词：苯胺 N-羟基邻苯二甲酰亚胺 氯化亚铜 2 2′-联吡啶 N-苯基邻苯二甲酰亚胺 

分 类 号：O625.6[理学—有机化学]