生物制造的市本率(PC值):定义与应用  

Price to Cost-of-raw-materials Ratio(PC)of biomanufacturing:definition and application

作　　者：张以恒 陈雪梅 石婷 ZHANG Yi-Heng PJob;CHEN Xuemei;SHI Ting(Key Laboratory of Engineering Biology for Low-Carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;In vitro Synthetic Biology Center,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;National Center of Technology Innovation for Synthetic Biology,Tianjin 300308,China)

机构地区：[1]中国科学院天津工业生物技术研究所,低碳合成工程生物学全国重点实验室,天津300308 [2]中国科学院天津工业生物技术研究所,体外合成生物学中心,天津300308 [3]国家合成生物技术创新中心,天津300308

出　　处：《合成生物学》2025年第1期8-17,共10页Synthetic Biology Journal

基　　金：国家重点研发计划“合成生物学”重点专项(2022YFA0912303);国家自然科学基金面上项目(NSFC 32271544);合成生物学海河实验室颠覆性创新项目(22HHSWSS000155);天津市合成生物技术创新能力提升行动项目(TSBICIP-CXRC-067)。

摘　　要：生物制造是中国“十四五”战略性新兴产业之一。本文作者曾经提出“道法术器”对工业生物制造的哲学指导意义。为了深入阐述生物制造中“法以立本”的原则,本文首次提出“市本率”这一创新性概念,即产品市场价格与原料成本的比值,英文全称是Price to Cost-of-raw-materials Ratio,简称PC值。市本率是一个衡量技术水平与经济价值的关键指标,具有简单、公开、透明的属性,提供了生物制造产品分类新方法,有助于指导新技术增效和降本的发展路径,预判生物产品未来制造成本及市场价格的趋势,评估新兴生物技术的产业化潜力。市本率的计算与分析,作为一种新方法学工具,将为生物制造战略新兴产业的未来发展提供顶层设计的新视角,深化对生物制造产品市场前景的理解,推动生物经济高质量发展。Biomanufacturing is one of the strategic emerging industries in China during the“14th Five-Year Plan”period.The author once proposed“Tao-Fa-Shu-Qi”for the industrial biomanufacturing and provided its philosophical guideline.Focusing on the“Fa”of biological manufacturing and further analyzing the concept of“Fa as rules”in biomanufacturing,the author first proposed the concept of“Price to Cost-of-raw-materials Ratio”(PC value),which is the ratio of product market price to cost with raw materials.Biomanufactured products can be categorized by PC value into high-value products,value-added products,biocommodity,and products for public good.The PC value is a key indicator for evaluating the technological capability and economic viability of biomanufactured products.It is simple,transparent,and publicly accessible,offering a new approach for categorizing biomanufactured products.This indicator aids in guiding new technologies towards pathways of efficiency enhancement and cost reduction,forecasting future manufacturing costs and market prices for bioproducts,and assessing the industrialization potential of emerging biotechnologies.This article focuses on the biomanufacturing of fructose syrup,fructose solution,crystalline fructose,allulose,myo-inositol,and tagatose as examples,analyzing pathways for developing new technologies and predicting their economic feasibility.The calculation and analysis of the PC value could provide a new methodological tool for the top-level strategic design of the future development of emerging biomanufacturing industries,and could effectively facilitate the high-quality development of the bioeconomy.

关 键 词：生物制造 生物经济 市本率 道法术器 第一性原理 大宗产品 

分 类 号：Q81[生物学—生物工程]