心肺康复运动联合沙库巴曲缬沙坦治疗急性心肌梗死后心功能不全患者的效果观察  

Investigating the Efficacy of Combining Cardiopulmonary Rehabilitation Exercise with Sacubitril and Valsartan for Treating Heart Failure Patients Post-Acute Myocardial Infarction

作　　者：唐敏 TANG Min(Department of Cardiology,Tongshan District People’s Hospital,Xuzhou,Jiangsu 221006,China)

机构地区：[1]徐州市铜山区人民医院心内科,江苏徐州221006

出　　处：《中国医药指南》2025年第8期84-87,共4页Guide of China Medicine

摘　　要：目的分析心肺康复运动+沙库巴曲缬沙坦应用在急性心肌梗死后心功能不全患者中的效果。方法选取2020年12月至2023年12月于徐州市铜山区人民医院心内科接受治疗的98例急性心肌梗死PCI术后心功能不全患者,将其按照随机数表方式分组,即对照组(n=49,沙库巴曲缬沙坦治疗)与观察组(n=49,心肺康复运动+沙库巴曲缬沙坦治疗)。对比两组心功能指标水平(N末端脑钠肽前体、左室射血分数、左室收缩末内径、左室舒张末内径)、6 min步行试验(6MWT)、血流动力学指标(心排血量、每搏输出量、每搏指数)、生活质量[明尼苏达心功能不全生命质量量表(MLHFQ)]评分和再住院发生率。结果治疗后,观察组心功能指标水平均优于对照组(P<0.05);观察组6MWT长于对照组(P<0.05);观察组心排血量、每搏输出量、每搏指数均高于对照组(P<0.05);观察组MLHFQ评分种身体、情绪和其他评分均高于对照组(P<0.05);观察组再住院发生率低于对照组(P<0.05)。结论心肺康复运动联合沙库巴曲缬沙坦治疗急性心肌梗死后心功能不全患者安全有效。Objective To evaluate the impact of combining cardiopulmonary rehabilitation exercise with valsartan in patients experiencing cardiac insufficiency following acute myocardial infarction.Methods A total of 98 patients with acute myocardial infarction and postoperative cardiac dysfunction who were admitted to the cardiology department of Tongshan District People’s Hospital in Xuzhou City from December 2020 to December 2023 were randomly divided into a control group(n=49,treated with sacubitril valsartan)and an observation group(n=49,treated with cardiopulmonary rehabilitation exercise+sacubitril valsartan)according to a random number table.The levels of cardiac function indicators nitrogen terminal-precursor of brain natriuretic peptide,left ventricular ejection fraction,left ventricular end-systolic diameter,left ventricular end-diastolic diameter,6-minute walk test(6MWT),hemodynamic indicators(cardiac output,stroke volume,stroke index),quality of life[Minnesota Cardiac Insufficiency Quality of Life Scale(MLHFQ)]score,and incidence of rehospitalization were compared between the two groups.Results Following treatment,the observation group demonstrated better cardiac function indicators compared to the control group(P<0.05).Additionally,the 6MWT results in the observation group were significantly longer than those in the control group(P<0.05).Cardiac output,stroke volume,and stroke volume index in the observation group were all higher(P<0.05).The MLHFQ scores,including physical,emotional,and other domains,were higher in the observation group compared to the control group(P<0.05).The control group exhibited a higher rehospitalization rate compared to the observation group(P<0.05).Conclusions The combination of cardiopulmonary rehabilitation exercise and sacubitril/valsartan is both safe and effective for treating heart failure patients following acute myocardial infarction.

关 键 词：急性心肌梗死 心肺康复运动 沙库巴曲缬沙坦 心功能不全 

分 类 号：R542.22[医药卫生—心血管疾病]