胆管结石发病机制中胆道微生物群的作用:最新研究进展  

Role of biliary microbiota in the pathogenesis of bile duct stones:latest research progress

作　　者：王潇宁 吴晓东(综述) 吴硕东[1] 韩金岩(审校)[1] WANG Xiaoning;WU Xiaodong;WU Shuodong;HAN Jinyan(Department of General SurgeryⅡ,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院第二普通外科,辽宁沈阳110004

出　　处：《外科理论与实践》2024年第6期544-549,共6页Journal of Surgery Concepts & Practice

摘　　要：胆管结石(BDS)的发病机制复杂,迄今尚未得到全面阐释。新近研究表明,胆道微生物群是导致BDS的重要原因。胆道微生物多样性与结石形成相关,细菌代谢产物及其自我保护机制也在结石形成中发挥关键作用。高通量测序等现代技术为深入研究提供了新视角,有望为胆道疾病防治提供新策略。本文就BDS与胆道微生物群的关系及机制的研究进展作一综述。The pathogenesis of bile duct stones(BDS)remains intricate and has not been fully elucidated to date.Emerging research has highlighted the biliary microbiota as a significant contributor to BDS.The diversity within the biliary microbiota correlates with stone formation,while bacterial metabolites and their self‐protection mechanisms also exert pivotal roles in this process.Advanced technologies,such as high‐throughput sequencing,offer fresh perspectives for in‐depth exploration,and hold promise for novel strategies in the prevention and treatment of biliary tract diseases.This article comprehensively reviewed the recent advancements in research concerning the relationship and mechanisms between BDS and the biliary microbiota.

关 键 词：胆管结石 胆道微生物群 高通量测序 

分 类 号：R657.42[医药卫生—外科学]