成纤维细胞激活蛋白抑制剂PET/CT在结直肠癌根治术后复发及转移中的应用进展  

Application advances of fibroblast activation protein inhibitor PET/CT in detecting recurrence and metastasis after radical surgery for colorectal cancer

作　　者：张斯强 叶芊芃 李光明(审校)[1] ZHANG Siqiang;YE Qianpeng;LI Guangming(Center of Imaging,The Affiliated Qingyuan Hospital,Guangzhou Medical University,Qingyuan People’s Hospital,Qingyuan 511518,China)

机构地区：[1]广州医科大学附属清远医院(清远市人民医院)影像中心,清远511518

出　　处：《国际医学放射学杂志》2025年第2期218-222,共5页International Journal of Medical Radiology

摘　　要：影像学评估对结直肠癌根治性手术后病人的随访具有重要作用。成纤维细胞激活蛋白抑制剂(FAPI)作为新兴的核素显像剂,其摄取不受糖代谢的影响,能提供更高的肿瘤背景比,更易发现复发病灶,尤其在非FDG亲和型肿瘤、腹膜转移及小病灶检测中具有较大优势。就FAPI PET/CT在结直肠癌根治术后复发及转移评估中的应用进展进行综述。Imaging assessment plays a crucial role in the follow-up of patients after radical surgery for colorectal cancer.Fibroblast activation protein inhibitor(FAPI),as an emerging radionuclide tracer,is not affected by glucose metabolism and offers a higher tumor-to-background ratio,making it more effective in detecting recurrent lesions.It is particularly advantageous in the detection of non-FDG-avid tumors,peritoneal metastases,and small lesions.This review summarizes the advances in the application of FAPI PET/CT for assessing recurrence and metastasis after radical surgery for colorectal cancer.

关 键 词：结直肠癌 正电子发射体层成像 成纤维细胞激活蛋白抑制剂 体层摄影术 X线计算机 

分 类 号：R817.8[医药卫生—影像医学与核医学] R817.9[医药卫生—放射医学]