三方基序蛋白13的生物学特征和功能及与疾病发生的关系  

The Biological Characteristics and Functions of TRIM13 and Its Relationship With The Development of Diseases

作　　者：姜淼 蒋丽娜 董玥宏[2] 姚咏明 赵自刚[2,4] 牛春雨[1,2,4] JIANG Miao;JIANG Li-Na;DONG Yue-Hong;YAO Yong-Ming;ZHAO Zi-Gang;NIU Chun-Yu(Basic Medical College,Hebei Medical University,Shijiazhuang 050017,China;Institute of Microcirculation/Basic Medical College,Hebei North University,Zhangjiakou 075000,China;Department of Immunology,School of Medical Laboratory,Hebei North University,Zhangjiakou 075000,China;Hebei Key Laboratory of Critical Disease Mechanism and Intervention,Hebei North University,Zhangjiakou 075000,China;Translational Medicine Research Center,Medical Innovation Research Division of the Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]河北医科大学基础医学院,石家庄050017 [2]河北北方学院基础医学院/微循环研究所,张家口075000 [3]河北北方学院医学检验学院免疫教研室,张家口075000 [4]河北北方学院河北省急危重症发病机制及干预重点实验室,张家口075000 [5]解放军总医院医学创新研究部转化医学研究中心,北京100853

出　　处：《生物化学与生物物理进展》2025年第3期554-568,共15页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(82130062)资助项目。

摘　　要：三方基序蛋白(tripartite motif-containing,TRIM)13具备一个独特的跨膜结构域,锚定在内质网,通过调节泛素化途径影响诸多关键信号通路,对于调节内质网功能以及免疫反应、代谢紊乱、炎症疾病和肿瘤抑制具有重要作用。本文综述TRIM13蛋白的结构和功能,特别是在内质网自噬、炎症反应和肿瘤抑制中的作用及其在多种疾病中的潜在意义,期望深化对TRIM13蛋白及其在相关疾病发生过程中调控机制的认识,为疾病诊断和治疗提供新的靶点。Tripartite motif-containing protein 13(TRIM13)is a crucial member of the TRIM protein family,distinguished by its unique transmembrane domain that anchors it to the endoplasmic reticulum(ER).As an E3 ubiquitin ligase,TRIM13 influences multiple key signaling pathways through ubiquitination regulation,playing significant roles in modulating ER function,immune responses,metabolic disorders,inflammatory diseases,and tumor suppression.TRIM13 possesses the common RING,B-box,and coiled-coil domains of the TRIM family,along with its distinctive transmembrane domain.Its E3 ubiquitin ligase activity serves as the structural basis for its diverse biological functions.TRIM13 acts as a non-canonical ER-phagy receptor to participate in regulating ER stress responses,recruiting LC3 through interaction with SQSTM1/p62 to initiate autophagy-mediated degradation of damaged ER,which is crucial for maintaining ER homeostasis and cellular function under stress conditions.TRIM13 is involved in inflammatory and antiviral immune responses by modulating key molecules in signaling pathways such as MDA5,NF-κB,and STING,highlighting its potential in regulating innate immunity and inflammatory responses.TRIM13 is associated with various pathological conditions,particularly in cancer and metabolic diseases.In multiple cancers,including non-small cell lung cancer,hepatocellular carcinoma,and acute myeloid leukemia,TRIM13 exhibits tumor-suppressive effects,with its expression levels closely associated with patient prognosis,suggesting its potential as a biomarker or therapeutic target in oncology.In diabetic nephropathy,TRIM13 improves renal function by promoting CHOP ubiquitination and inhibiting interstitial collagen synthesis,demonstrating its protective role in kidney disease.In atherosclerosis,TRIM13 is involved in regulating cholesterol metabolism and inflammatory pathways,indicating its significance in cardiovascular disorders.Recent studies have also implicated TRIM13 in neurodegenerative disorders and metabolic syndromes,with its role

关 键 词：三方基序蛋白13 泛素化 内质网自噬 免疫调控 

分 类 号：Q291[生物学—细胞生物学]