非侵入性光生物调节治疗技术在阿尔茨海默病中的应用  

Non-invasive Photobiomodulation Therapy Techniques in Alzheimer’s Disease

作　　者：郭延光 魏双红 王韵乐 陈思 HOSSEIN Chamkouri 陈鹏[4] 司健敏[4] 牛朝诗 陈雷[1,5] GUO Yan-Guang;WEI Shuang-Hong;WANG Yun-Le;CHEN Si;HOSSEIN Chamkouri;CHEN Peng;SI Jian-Min;NIU Chao-Shi;CHEN Lei(School of Materials Science and Engineering,Hefei University of Technology,Hefei 230009,China;Basic Medical College,Air Force Medical University,Xi’an 710032,China;School of Medicine,Huainan Union University,Huainan 232038,China;Department of Neurosurgery,The First Affiliated Hospital of USTC,Hefei 230001,China;Institute of Intelligent Manufacturing,Hefei University of Technology,Hefei 230051,China)

机构地区：[1]合肥工业大学材料科学与工程学院,合肥230009 [2]空军军医大学基础医学院,西安710032 [3]淮南联合大学医学院,淮南232038 [4]中国科学技术大学附属第一医院(安徽省立医院)神经外科,合肥230001 [5]合肥工业大学智能制造技术研究院,合肥230051

出　　处：《生物化学与生物物理进展》2025年第3期654-668,共15页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(21875058);安徽省自然科学基金(2208085J13);2022年度中山市重大科技专项战略性新兴产业技术攻关专题(2022A1007)资助项目。

摘　　要：随着中国人口结构老龄化,公共卫生领域迫切需要应对阿尔茨海默病(Alzheimer’s disease,AD)带来的重大社会发展问题。AD临床治疗能够使用的药物十分有限且使用一段时间后治疗效果不佳。尽管全球投入大量物力和财力进行药物研发,但药物治疗临床试验进展十分缓慢。近30年来,仅有7款AD药物获得美国食品药品监督管理局(Food and Drug Administration,FDA)批准。传统药物治疗价格昂贵且只能起到延缓AD病情作用,而无法阻止神经元进行性退化过程。因此,探究发展AD新兴治疗手段刻不容缓。光生物调节(photobiomodulation,PBM)是一种非侵入性的治疗方法,利用红光或近红外光刺激细胞代谢和细胞学反应。PBM可以改善脑部代谢和血液循环,修复脑部受损神经元,激发树突和神经元生长,有望发展成为与药物治疗互补的无创伤神经治疗手段。本文阐述了AD病理学特征、致病机理与现有治疗策略面临的难题,综述了PBM治疗AD的细胞与动物模型和临床研究,总结了光疗历史与先进PBM光疗设备研发现状,最后对发展用于AD PBM治疗的先进光子技术与光疗器械装备进行了展望。As the aging population in China continues to grow,the country’s public health sector faces an urgent need to address the significant social challenges posed by Alzheimer’s disease(AD).The available clinical treatments for AD are extremely limited,and the effectiveness of these drugs often diminishes after a period of use.Despite substantial global investment in drug research and development,the progress of clinical trials for AD treatments has been exceedingly slow.Over the past 30 years,only seven AD drugs have been approved by the U.S.Food and Drug Administration(FDA).Traditional drug therapies are expensive and can only slow the progression of AD,without halting the progressive degeneration of neurons.Therefore,exploring and developing emerging treatment methods for AD is imperative.Photobiomodulation(PBM)is a non-invasive therapeutic approach that uses red or near-infrared light to stimulate cellular metabolism and biological responses.PBM has the potential to improve brain metabolism and blood circulation,repair damaged neurons in the brain,and stimulate dendritic and neuronal growth,making it a promising non-invasive neurotherapeutic method that could complement drug treatments.This paper discusses the pathological characteristics and pathogenic mechanisms of AD,as well as the challenges faced by existing treatment strategies.It also reviews the research on PBM treatment in AD cellular and animal models and clinical studies,summarizes the history of phototherapy and the current state of advanced PBM phototherapy device development,and finally offers a perspective on the future development of advanced photonic technologies and therapeutic devices for PBM treatment of AD.

关 键 词：阿尔茨海默病 光生物调节 发光二极管光源 医疗器械 光子技术 

分 类 号：R454[医药卫生—治疗学] R749[医药卫生—临床医学]