重性抑郁障碍神经调控应用及评估  

Application and Evaluation of Neuromodulation in Major Depressive Disorder

作　　者：李玉清 揭会聪 郭江子慧 刘迢迢 郑旭媛 LI Yu-Qing;JIE Hui-Cong;GUO Jiang-Zi-Hui;LIU Tiao-Tiao;ZHENG Xu-Yuan(School of Biomedical Engineering and Technology,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学生物医学工程与技术学院,天津300070

出　　处：《生物化学与生物物理进展》2025年第3期681-690,共10页Progress In Biochemistry and Biophysics

基　　金：天津市科技计划(23JCYBJC00210)资助项目。

摘　　要：抑郁症又称重性抑郁障碍(MDD),是以情绪低落、兴趣减退和精力缺乏为主要特征的情感障碍类疾病,给家庭和社会造成沉重的负担。神经调控技术通过侵入性或非侵入性的方法,利用电、磁等手段调节大脑特定区域的神经活动,改善抑郁症状。确定客观的评估指标可以为MDD神经调控策略的制定及疗效评估提供可靠的依据。本文系统回顾经颅磁刺激(TMS)、经颅电刺激(TES)和经颅超声刺激(TUS)等非侵入式,以及深部脑刺激(DBS)、光遗传学和化学遗传学等侵入式神经调控技术在MDD的最新应用进展,重点探讨了神经调控的行为学、神经影像学以及神经电生理评估指标,为未来开发重性抑郁障碍的精准、个性化神经调控方案和评估工具提供方向。Depression,also known as major depressive disorder(MDD),is an emotional disorder characterized by low mood,decreased interest,and lack of energy,which imposes a heavy burden on families and society.Neuromodulation technology has made significant progress in improving depressive symptoms by using invasive or non-invasive methods,such as electricity and magnetism,to regulate neural activity in specific areas of the brain.Determining objective evaluation indicators can provide reliable basis for the development of neural regulation strategies and efficacy evaluation in MDD.This article systematically reviews the latest application progress of non-invasive neural regulation techniques such as transcranial magnetic stimulation(TMS),transcranial electrical stimulation(TES),and transcranial ultrasound stimulation(TUS),as well as invasive neural regulation techniques such as deep brain stimulation(DBS),optogenetics,and chemical genetics in MDD.The focus is on exploring behavioral,neuroimaging,and neurophysiological evaluation indicators of neural regulation,providing direction for the development of precise and personalized neural regulation schemes and assessment tools for MDD in the future.

关 键 词：重性抑郁障碍 非侵入式调控 侵入式调控 评估指标 

分 类 号：R318[医药卫生—生物医学工程] Q426[医药卫生—基础医学]