灵芝纳米的制备及应用研究进展  

Advances in Preparation and Application of Ganoderma lucidum Nanoparticles

作　　者：王燕[1] 秦慧妮 冯佳乐 刘艳丽[2] 郭锐 李俊耀 纪丽莲 王桃云[1] WANG Yan;QIN Huini;FENG Jiale;LIU Yanli;GUO Rui;LI Junyao;JI Lilian;WANG Taoyun(School of Chemistry and Life Sciences,Suzhou University of Science and Technology,Suzhou 215009,China;School of Pharmacy,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州科技大学化学与生命科学学院,江苏苏州215009 [2]苏州大学药学院,江苏苏州215123

出　　处：《中国药学杂志》2025年第2期144-152,共9页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金面上项目资助(82073912)。

摘　　要：灵芝(Ganoderma lucidum)是多孔菌科灵芝属真菌,是一种药食两用的珍贵药材,具有抗氧化、抗菌、抗肿瘤、抗炎及神经保护等多种生物活性。然而,由于灵芝不易溶解、生物利用率低、难以被人体吸收以及直接使用会增加肝损伤患者的肝脏负担等原因,灵芝的应用受到很大限制。近年来,为了提高灵芝的应用功效并扩大其运用范围,灵芝纳米化研究受到研究人员的广泛关注。笔者介绍了灵芝纳米的制备(包括生物法、化学法和物理法)及其在生物医药保健、环境、农业等领域的应用及作用机制,指出了现有相关研究存在的不足及今后的发展方向,为灵芝纳米的深入研究提供参考。Ganoderma lucidum is a fungus belonging to the genus Ganoderma in the family of Polyporaceae.As a precious medicinal herb which can be used for both medicine and food,it has various biological activities such as antioxidant,antibacterial,anti-tumor,anti-inflammatory,and neuroprotective properties.However,due to the difficulty in dissolution,low bioavailability,difficulty in absorption by the human body,and the increased burden on liver injury patients caused by direct use,the application of Ganoderma lucidum is greatly limited.In recent years,in order to improve the application efficiency of Ganoderma lucidum and expand its scope of application,the research on its nanoparticle size has received widespread attention from researchers.The article introduces the preparation of Ganoderma lucidum nanoparticles(including biological,chemical and physical methods)and their applications and mechanisms of action in different fields such as biomedicine,health care,environment and agriculture.It points out the shortcomings of existing related research and future development directions,and provides reference for in-depth research on Ganoderma lucidum nanoparticles.

关 键 词：灵芝 纳米颗粒 制备方法 应用领域 

分 类 号：R944[医药卫生—药剂学]