丁苯酞软胶囊联合左旋多巴和多巴丝肼对老年帕金森病患者运动功能及同型半胱氨酸、IGF-1水平的影响  

Effects of DL-3-n-butylphthalide Soft Capsules Combined with Levodopa and Benserazide on Motor Function and Homocysteine and IGF-1 Levels in Elderly Patients with Parkinson's Disease

作　　者：陈衍 胡娅娜 CHEN Yan;HU Yana(Jinhua Traditional Chinese Medicine Hospital,Jinhua 321017,China)

机构地区：[1]浙江省金华市中医医院,浙江金华321017

出　　处：《中国药学杂志》2025年第2期189-193,共5页Chinese Pharmaceutical Journal

基　　金：金华市中医药科学技术项目资助(2022KY22)。

摘　　要：目的探究丁苯酞(DL-3-n-butylphthalide,NBP)软胶囊联合左旋多巴和多巴丝肼(levodopa and benserazide,LB)对老年帕金森病(Parkinson's disease,PD)患者运动功能及血清同型半胱氨酸(homocysteine,Hcy)、胰岛素样生长因子1(insulin-like growth factor-1,IGF-1)的影响。方法将2021年3月至2023年3月浙江省金华市中医医院收治的100例老年中晚期PD患者纳入本次回顾性研究,根据治疗方法不同分成对照组(n=50)和观察组(n=50),对照组患者接受LB治疗,观察组患者接受LB+NBP软胶囊治疗,治疗持续1年。比较两组的临床疗效、治疗前后的统一帕金森病评定量表(unified Parkinson's disease rating scale,UPDRS)评分、Hoehn-Yahr分期及UPDRS-Ⅲ评分及血清Hcy、IGF-1。结果观察组的临床疗效显著优于对照组(P<0.05);两组治疗1年后的UPDRS评分、Hoehn-Yahr分期、UPDRS-Ⅲ评分均较治疗前显著下降,且观察组治疗1年后的UPDRS评分、Hoehn-Yahr分期、UPDRS-Ⅲ评分显著低于对照组(P<0.05);两组治疗1年后的血清Hcy较对照组显著降低,而血清IGF-1刚好相反,且观察组治疗1年后的血清Hcy显著低于对照组,而血清IGF-1显著高于对照组(P<0.05)。结论在老年中晚期PD患者中,NBP软胶囊联合LB可显著降低血清Hcy,显著提高IGF-1,显著改善患者的运动功能。OBJECTIVE To investigate the effects of DL-3-n-butylphthalide(NBP)soft capsules combined with levodopa and benserazide(LB)on the motor function and serum homocysteine(Hcy)and insulin-like growth factor 1(IGF-1)levels in elderly patients with Parkinson's disease(PD).METHODS One hundred elderly patients with mid to late-stage PD admitted to our hospital from March 2021 to March 2023 were included in this retrospective study and divided into control group(n=50)and observation group(n=50)based on different treatment methods.The control group received treatment with LB,while the observation group received treatment with LB and NBP soft capsules for a duration of 1 year.The clinical efficacy,Unified Parkinson's Disease Rating Scale(UPDRS)scores,Hoehn-Yahr stage,UPDRS-Ⅲscores,serum Hcy levels,and IGF-1 levels before and after treatment were compared.RESULTS The clinical effect of the observation group was dramatically better than that of the control group(P<0.05).After 1 year of treatment,both groups showed significant reduction in UPDRS scores,Hoehn-Yahr stage,and UPDRS-Ⅲscores compared to baseline.Furthermore,the observation group had dramatically lower UPDRS scores,Hoehn-Yahr stage,and UPDRS-Ⅲscores compared to the control group(P<0.05).After 1 year of treatment,serum Hcy levels were dramatically lower in the observation group compared to the control group,while serum IGF-1 levels were dramatically higher(P<0.05).CONCLUSION In elderly patients with mid to late-stage PD,NBP soft capsules combined with LB can significantly reduce serum Hcy levels,increase IGF-1 levels,and improve motor function in patients with PD.

关 键 词：帕金森 丁苯酞软胶囊 左旋多巴 多巴丝肼 同型半胱氨酸 胰岛素样生长因子1 

分 类 号：R917[医药卫生—药物分析学]