河北地区呼吸道感染住院患儿人偏肺病毒流行病学特征分析  

Epidemiological characteristics of human metapulmonaryvirus in hospitalized children with respiratory infections in Hebei Province

作　　者：杜鸿飞 赵梦川 张晓双 周珊珊[1] 黄晶[1] 刘新光[1] Du Hongfei;Zhao Mengchuan;Zhang Xiaoshuang;Zhou Shanshan;Huang Jing;Liu Xinguang(Laboratory Department of Hebei Children′s Hospital,Shijiazhuang 050031,China)

机构地区：[1]河北省儿童医院检验科,石家庄050031

出　　处：《中华微生物学和免疫学杂志》2025年第2期93-98,共6页Chinese Journal of Microbiology and Immunology

基　　金：河北省医学科学研究课题计划(20231136)。

摘　　要：目的探讨河北地区急性呼吸道感染住院患儿人偏肺病毒(human metapneumovirus,hMPV)的流行病学特征,为河北地区儿童急性呼吸道感染的临床诊治提供理论依据。方法回顾性纳入2017年1月—2021年12月因急性呼吸道感染在河北省儿童医院住院治疗的41499例患儿,分析不同性别、年龄、季节患儿的发病情况,并对hMPV阳性检出率、与其他病原体混合检出情况以及临床诊断等流行病学资料进行统计分析。结果2017—2021年急性呼吸道感染住院患儿hMPV的总阳性检出率为5.94%(2464/41499),3~4岁年龄组患儿的hMPV阳性检出率(7.66%,520/6789)最高,≥5岁年龄组患儿阳性检出率(2.89%,180/6225)最低,差异有统计学意义(P<0.001);男性患儿和女性患儿的阳性检出率分别为5.97%(1496/25056)和5.94%(968/16443),差异无统计学意义(P>0.05)。2017—2021年hMPV的阳性检出率分别为5.10%(408/7998)、9.64%(915/9491)、4.27%(426/9969)、5.91%(368/6226)和4.44%(347/7815),2018年hMPV的阳性检出率明显高于其他年份(P<0.001)。hMPV常年散发,具有明显的季节性,春、冬两季阳性检出率最高。hMPV与其他呼吸道病原体的混合检出率为42.74%(1053/2464),其中与鼻病毒混合检出最为常见,混合检出率为48.24%(508/1053)。hPMV阳性患儿的临床诊断以支气管肺炎多见。结论hMPV是河北地区急性呼吸道感染住院患儿的重要病原体之一,5岁以下儿童多见,全年均可发生,流行高峰在冬、春两季,常与其他呼吸道病原体混合检出,与其他病原体混合检出有加重患儿临床症状的风险。Objective To explore the epidemiological characteristics of human metapneumovirus(hMPV)in children hospitalized for acute respiratory tract infections in Hebei,and provide a theoretical basis for the clinical diagnosis and treatment of acute respiratory tract infections in children in Hebei.MethodsRetrospectively,41499 children hospitalized in Hebei Children′s Hospital for acute respiratory tract infections from January 2017 to December 2021 were included to analyze the morbidity of children of different genders and ages,and in different seasons,and to statistically analyze the epidemiological data such as the positive detection rate of hMPV,the detection rates of mixed infections with other pathogens,and the clinical diagnosis.ResultsThe overall positive detection rate of hMPV in hospitalized children with acute respiratory infections from 2017 to 2021 was 5.94%(2464/41499),with the highest positive detection rate of hMPV in the age group of 3 to 4 years(7.66%,520/6789)and the lowest in the age group of≥5 years(2.89%,180/6225),with a statistically significant difference(P<0.001);the positive detection rates in male and female children were respectively 5.97%(1496/25056)and 5.94%(968/16443),and the difference was not statistically significant(P>0.05).The positive detection rates of hMPV from 2017 to 2021 were 5.10%(408/7998),9.64%(915/9491),4.27%(426/9969),5.91%(368/6226),and 4.44%(347/7815),respectively,and the positive detection rate of hMPV in 2018 was significantly higher than that in the other years(P<0.001).hMPV circulated throughout the year,with obvious seasonality,with the highest positive detection rate in spring and winter.The mixed detection rate of hMPV with other respiratory pathogens was 42.74%(1053/2464),of which mixed detection with rhinovirus was the most common,with a mixed detection rate of 48.24%(508/1053).Clinical diagnosis of hPMV-positive children was mostly bronchopneumonia.ConclusionshMPV is one of the important pathogens in hospitalized children with acute respiratory infections in

关 键 词：人偏肺病毒 急性呼吸道感染 流行病学特征 儿童 

分 类 号：R72[医药卫生—儿科]