戊型肝炎病毒ORF2分泌型蛋白研究进展  

Progress in soluble secreted form of hepatitis E virus ORF2 protein

作　　者：耿彦生[1] 赵晨燕[2] Geng Yansheng;Zhao Chenyan(School of Public Health,Hebei University,Baoding 071000,China;Division of HIV/AIDS and Sex-Transmitted Virus Vaccines,National Institutes for Food and Drug Control,Beijing 102629,China)

机构地区：[1]河北大学公共卫生学院,保定071000 [2]中国食品药品检定研究院艾滋病性病病毒疫苗室,北京102629

出　　处：《中华微生物学和免疫学杂志》2025年第2期149-155,共7页Chinese Journal of Microbiology and Immunology

基　　金：河北省自然科学基金(H2021201015)。

摘　　要：戊型肝炎病毒(HEV)的基因组含有3个开放编码框(ORF1~3),其中ORF2编码的ORF2蛋白构成病毒衣壳。一直认为ORF2蛋白是HEV病毒体的结构蛋白,只构成病毒衣壳。最近发现,HEV复制过程中,ORF2除编码产生病毒衣壳蛋白外,还产生大量糖基化蛋白,以可溶性蛋白质的形式分泌到宿主细胞外,称为ORF2分泌型蛋白(ORF2S)。ORF2S不参与感染性病毒粒子的组装,但在HEV感染和致病过程中可能发挥重要作用。本文对有关HEV ORF2S的研究进展进行综述。The genome of hepatitis E virus(HEV)contains three open reading frames(ORF1-3),among which ORF2 encodes the viral capsid protein.It has been believed that ORF2 only encodes the structural protein for assembling the capsid of HEV virion.However,recent findings have revealed that during HEV replication,ORF2 also produces a substantial amount of glycosylated soluble protein secreted outside the host cells,known as the ORF2 secreted form(ORF2S).Although not involved in virion assembly,the soluble secreted form of ORF2 protein may play a crucial role in HEV infection and pathogenesis.This review presents an overview of research progress in HEV ORF2S.

关 键 词：戊型肝炎病毒 衣壳蛋白 非结构蛋白 ORF2分泌型蛋白 糖基化ORF2蛋白 

分 类 号：S85[农业科学—兽医学]