补肺化瘀通络汤联合低分子肝素钙对慢性肺栓塞(气虚血瘀证)患者的疗效研究  

Study on the Therapeutic Effect of Bu Fei Hua Yu Tong Luo Tang Combined with Low Molecular Weight Heparin Calcium on Patients with Chronic Pulmonary Embolism(Qi Deficiency and Blood Stasis Syndrome)

作　　者：刘继永[1] 常惠忠 郝坤[3] 郝妍丽 王广云 LIU Ji-yong;CHANG Hui-zhong;HAO Kun;HAO Yan-li;WANG Guang-yun(Department of Internal Medicine,Suqian Traditional Chinese Medicine Hospital/The Affiliated Hospital of Nanjing University of Chinese Medicine,Suqian,Jiangsu,223800,China;Department of Traditional Chinese Medicine,Suqian Traditional Chinese Medicine Hospital/The Affiliated Hospital of Nanjing University of Chinese Medicine,Suqian,Jiangsu,223800,China;Department of Encephalopathy,Suqian Traditional Chinese Medicine Hospital/The Affiliated Hospital of Nanjing University of Chinese Medicine,Suqian,Jiangsu,223800,China;Department of Emergency,Suqian Traditional Chinese Medicine Hospital/The Affiliated Hospital of Nanjing University of Chinese Medicine,Suqian,Jiangsu,223800,China)

机构地区：[1]宿迁市中医院/南京中医药大学附属医院内科,江苏宿迁223800 [2]宿迁市中医院/南京中医药大学附属医院中医科,江苏宿迁223800 [3]宿迁市中医院/南京中医药大学附属医院脑病科,江苏宿迁223800 [4]宿迁市中医院/南京中医药大学附属医院急诊科,江苏宿迁223800

出　　处：《现代生物医学进展》2025年第3期444-450,共7页Progress in Modern Biomedicine

基　　金：江苏省中医药管理局科技发展计划项目(YB2020093)。

摘　　要：目的:研究补肺化瘀通络汤联合低分子肝素钙对慢性肺栓塞(气虚血瘀证)患者的疗效。方法:选择2021年1月~2024年1月于我院诊治的80例慢性肺栓塞患者,用抽签法随机分为两组。对照组采用低分子肝素钙,观察组采用补肺化瘀通络汤联合低分子肝素钙。比较两组的疗效、肺功能和炎症因子水平。结果:观察组的有效率[92.50%(37/40)]明显高于对照组[70.00%(28/40)](P<0.05);治疗后,两组的呼吸频率(RR)、最大肺活量(VCmax)、潮气量(VT)、呼气峰值流量(PEF)和达峰容积比(VPTEF/VE)均明显改善(P<0.05),且观察组的RR、VCmax、VT、PEF和VPTEF/VE明显优于对照组(P<0.05);治疗后,两组的血清C反应蛋白(CRP)、白细胞介素-4(IL-4)、高迁移率族蛋白B1(HMGB-1)和白细胞介素-8(IL-8)水平降低,且观察组低于对照组(P<0.05);观察组的恶心、粪便隐血、肝肾功能异常、头晕和皮肤黏膜出血发生率发生率[22.50%(9/40)]与对照组[17.50%(7/40)]相比无明显差异(P>0.05)。结论:补肺化瘀通络汤联合低分子肝素钙能有效改善慢性肺栓塞(气虚血瘀证)患者的肺功能,减轻炎症反应,安全有效。Objective:Study the therapeutic effect of Bu Fei Hua Yu Tong Luo Tang combined with low molecular weight heparin calcium on patients with chronic pulmonary embolism(Qi deficiency and blood stasis syndrome).Methods:Select 80 patients with chronic pulmonary embolism treated in our hospital from January 2021 to January 2024,and randomly divide them into two groups using the drawing method.The matched group was treated with low molecular weight heparin calcium,while the observation group was treated with Bu Fei Hua Yu Tong Luo Tang combined with low molecular weight heparin calcium.Compare the efficacy,lung function inflammatory factors levels between the two groups.Results:The effective rate of the observation group was higher than that of the matched group(P<0.05).post-treatment,the respiratory rate(RR),maximum vital capacity(VCmax),tidal volume(VT),peak expiratory flow(PEF),and peak to volume ratio(VPTEF/VE)of both groups were improved(P<0.05),and RR,VCmax,VT,PEF,and VPTEF/VE in the observation group were better than those in the matched group(P<0.05).post-treatment,the levels of serum C-reactive protein(CRP),interleukin-4(IL-4),high mobility group protein B1(HMGB-1),and interleukin-8(IL-8)were reduced in both groups(P<0.05),and the observation group were lower than matched group(P<0.05).The incidence of nausea,fecal occult blood,liver and kidney dysfunction,dizziness,and skin and mucosal bleeding in the observation group[22.50%(9/40)]showed no difference compared to the matched group[17.50%(7/40)](P>0.05).Conclusion:The combination of Bu Fei Hua Yu Tong Luo Tang and low molecular weight heparin calcium can effectively improve the lung function of patients with chronic pulmonary embolism(Qi deficiency and blood stasis syndrome),reduce inflammatory reactions,and is safe and effective.

关 键 词：补肺化瘀通络汤 低分子肝素钙 慢性肺栓塞 气虚血瘀证 肺功能 炎症指标 

分 类 号：R3[医药卫生—基础医学] R256.1R563.5