肺动脉高压患者血清NT-proBNP、IL-6与klotho水平及其诊断价值  

Serum Levels of NT-proBNP,IL-6 and Klotho and Their Diagnostic Value for Patients with Pulmonary Arterial Hypertension

作　　者：卓建 陆晓晨[1] 范勐慷 姚莉红 陆玮玮 盛红专[1] ZHUO Jian;LU Xiao-chen;FAN Meng-kang;YAO Li-hong;LU Wei-wei;SHENG Hong-zhuan(Department of Cardiovascular,Affiliated Hospital of Nantong University,Nantong,Jiangsu,226000,China)

机构地区：[1]南通大学附属医院心血管内科,江苏南通226000

出　　处：《现代生物医学进展》2025年第3期451-458,共8页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年基金项目(82000380);南通市科技局重点项目(MS22020008)。

摘　　要：目的:分析肺动脉高压(PAH)患者血清氨基末端B型利钠肽前体(NT-proBNP)、白介素-6(IL-6)与克罗素(klotho)水平,并探讨其在诊断PAH中的临床价值。方法:选取2020年2月至2021年8月在我院行右心漂浮导管检查的患者共44例,根据右心导管检查结果将患者分为PAH组(23例)、正常组(21例)。采用化学发光法检测患者血清NT-proBNP水平,双抗夹心酶联免疫吸附试验法(ELISA)检测患者血清IL-6、klotho蛋白水平,分析患者血清NT-proBNP、IL-6与klotho水平与其临床特征的相关性,采用受试者工作特征曲线(ROC)评估血清IL-6、NT-proBNP与klotho水平单用或联合应用对PAH的诊断价值。结果:PAH组血清IL-6、NT-proBNP与klotho蛋白水平较对照组均明显升高,差异均有统计学意义(P<0.05)。PAH组的血清NT-proBNP与klotho水平存在显著正相关性。klotho联合NT-proBNP诊断PAH的ROC曲线下面积(AUC)为0.9193,大于IL-6、NT-proBNP、klotho单独诊断PAH的ROC曲线下面积(0.7526、0.824、0.8406)以及三者联合诊断PAH的ROC曲线下面积(0.9172)。结论:肺动脉高压患者血清NT-proBNP、IL-6与klotho水平明显升高,且血清NT-proBNP与klotho水平联合诊断PAH的临床价值明显高于NT-proBNP、IL-6与klotho单独或三者联合检测。Objective:To analyze the serum levels of amino-terminal pro-brain natriuretic peptide(NT-proBNP),interleukin-6(IL-6),and klotho in patients with pulmonary arterial hypertension(PAH),and explore their clinical value for the diagnosis of PAH.Methods:A total of 44 patients who underwent right heart floating catheter examination at our institution from February 2020 to August 2021 were selected.Based on the results of the right heart catheterization,the patients were divided into two groups:the pulmonary arterial hypertension(PAH)group(23 cases)and the normal group(21 cases).The serum levels of NT-proBNP were measured using chemiluminescent methods,while serum levels of IL-6 and Klotho protein were assessed using a double-antibody sandwich enzyme-linked immunosorbent assay(ELISA).The correlation between serum NT-proBNP,IL-6,and Klotho levels and the clinical characteristics of patients was analyzed.The diagnostic value of serum IL-6,NT-proBNP,and Klotho levels,both individually and in combination,for PAH was evaluated using receiver operating characteristic(ROC)curves.Results:The levels of serum IL-6,NT-proBNP and klotho protein in PAH group were significantly higher than those in the control group(P<0.05).There was a significant positive correlation between serum NT-proBNP and klotho level in PAH group.The area under ROC curve(AUC)of klotho combined with NT-proBNP in the diagnosis of PAH was 0.9193.The area under ROC curve greater than that of IL-6,NT-proBNP and klotho for the diagnosis of PAH alone(0.7526,0.824,0.8406)and the area under ROC curve for the diagnosis of PAH by the combination of IL-6,NT-probNP and Klotho(0.9172).Conclusion:Serum levels of NT-proBNP,IL-6,and klotho are significantly elevated in patients with PAH.Furthermore,the clinical value of the combined assessment of serum NT-proBNP and klotho levels in diagnosing PAH is markedly higher than that of NT-proBNP,IL-6,or klotho assessed individually or in combination.

关 键 词：肺动脉高压 NT-PROBNP KLOTHO 白介素-6 

分 类 号：R3[医药卫生—基础医学] R541.61