激光疗法联合非甾体抗炎药口服对髌骨软化症疼痛程度及炎症因子水平影响  

Effect of Laser Therapy Combined with Oral Administration of non-steroidal Anti-inflammatory Drugs on the Pain Level and Inflammatory Factor Levels of Patellar Osteomalacia

作　　者：朱健奎 环安石 王韶光 陈凌云 田涛 ZHU Jian-kui;HUAN An-shi;WANG Shao-guang;CHEN Ling-yun;TIAN Tao(Department of Orthopedics,Yangzhou Hospital of Traditional Chinese Medicine,Yangzhou,Jiangsu,225009,China)

机构地区：[1]扬州市中医院骨科,江苏扬州225009

出　　处：《现代生物医学进展》2025年第3期481-487,共7页Progress in Modern Biomedicine

基　　金：中国医药教育协会项目(ZXRH-ERAS-001)。

摘　　要：目的:研究激光疗法联合非甾体抗炎药物口服治疗对髌骨软化症患者疼痛程度和血清炎症因子的影响。方法:2021.6-2023.6接受治疗的髌骨软化症患者160例,分为对照组和研究组,每组80例。对照组给予非甾体抗炎药物和玻璃酸钠注射液治疗,研究组患者在对照组治疗基础上加用激光器局部照射治疗。比较两组患者临床疗效、疼痛视觉模拟评分法(VAS)评分、Lysholm膝关节评分量表(LKSS)、Kujala髌骨评分测试(KPST)评分以及血清C反应蛋白(CRP)、白介素-6(IL-6)含量。结果:两组患者治疗后临床疗效总有效率比较无显著差异(P>0.05),但研究组患治愈率显著高于对照组患者(72.50%vs 43.75%,P<0.05)。两组患者治疗前VAS、LKSS、KPST以及血清CRP、IL-6含量具有可比性(P>0.05),治疗后均发生显著改变(P<0.05)。研究组患者治疗14天和35天疼痛VAS评分显著低于对照组患者(P<0.05);并且研究组组患者治疗后LKSS评分和KPST评分均显著高于对照组患者(P<0.05),而血清CRP和IL-6含量均显著低于对照组患者(P<0.05)。结论:激光疗法联合非甾体抗炎药物治疗髌骨软化症临床疗效较好,可有效缓解患者疼痛和降低血清炎症因子水平。Objective:To investigate the effect of laser therapy combined with oral treatment of non-steroidal anti-inflammatory drugs on pain levels and serum inflammatory factors in patients with chondromia.Methods:2021.6-2023.6160 patients with patellar osteomalacia were treated into control and study groups,80 patients in each group.The patients in the Matched group were treated with non-steroidal anti-inflammatory drugs and physiotherapy,and the patients in the study group were treated with local irradiation with infrared therapy device on the basis of the treatment in the Matched group.The clinical efficacy,pain visual analogue scale(VAS)score,Lysholm Knee Rating Scale(LKSS),Kujala Patella Scoring Test(KPST)score,and serum C-reactive protein(CRP)and interleukin-6(IL-6)levels were compared between the two groups.Results:There was no difference in the total effective rate of clinical efficacy between the two groups(P>0.05),but the cure rate in the study group was higher than that in the Matched group(72.50%vs 43.75%,P<0.05).The levels of VAS,LKSS,KST,and serum CRP and IL-6 in the two groups were comparable Pretherapy(P>0.05),and they all changed post-treatment(P<0.05).The pain VAS scores of the patients in the study group after 14 days and 35days of treatment were lower than those in the Matched group(P<0.05).The LKSS score and KPST score in the study group were higher than those in the Matched group(P<0.05),while the serum CRP and IL-6 contents were lower than those in the Matched group(P<0.05).Conclusion:Laser therapy combined with non-steroidal anti-inflammatory drugs has good clinical efficacy in the treatment of patellar malacia,which can effectively relieve pain and reduce serum inflammatory factor levels.

关 键 词：非甾体药物 激光疗法 髌骨软化症 炎症因子 

分 类 号：R3[医药卫生—基础医学] R681