Macroporous scaffolds based on biomass polymers and their applications in wound healing  

作　　者：Daqian Gao William D.Shipman Yaping Sun Joshua Zev G.lahn Leleda Beraki Henry C.Hsia 

机构地区：[1]Division of Plastic and Reconstructive Surgery,Department of Surgery,Yale School of Medicine,Yale University,New Haven,CT,USA [2]VA Connecticut Healthcare,West Haven,Connecticut,USA [3]Department of Dermatology,Yale School of Medicine,Yale University,New Haven,Connecticut,USA [4]Section of Infectious Diseases,Department of Internal Medicine,Yale School of Medicine,Yale University,New Haven,Connecticut,USA [5]Department of Biomedical Engineering,Yale University,New Haven,Connecticut,USA

出　　处：《Journal of Bioresources and Bioproducts》2025年第1期14-31,共18页生物质资源与工程(英文)

基　　金：supported by a Merit Award from the Veterans Health Administration-Office of Research and Development(VA-ORD BLR&D Merit Award,BX-19-001).

摘　　要：The rapid advancement of biomedical polymers has raised significant concerns about the disposal of medical polymer waste.Sustainable biomass materials derived from renewable sources in na-ture have emerged as promising alternatives to petroleum-based polymers for medical applica-tions and tissue engineering due to their abundance,biodegradability,and environmental friend-liness.In tissue engineering,interconnected macropores within biomaterials are crucial as they provide space and interfaces for cells,enhancing permeability for nutrient and waste transport.In this review,we summarize recent developments in the use of biomass materials to engineer macroporous tissue engineering scaffolds.We highlight key techniques,such as microparticles assembly,leaching template,and bioprinting that can create macropores within scaffolds com-posed of biomass materials and their composites.In addition,we investigate the applications of the macroporous scaffolds in wound healing,with a focus on cell behaviors within macroporous constructs and their role in treating chronic wounds.We envision that the combination of the bicontinuous macropores and biomass-based materials can create an ideal cellular environment and provide a powerful platform for wound healing and tissue regeneration.

关 键 词：Biomass material Bioresource MACROPORE Tissue engineering Wound healing 

分 类 号：O64[理学—物理化学]