A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin  

作　　者：Bowei Wang Dingkun Qiu Yihui Gu Zhu Shan Ruonan Shi Jing Luo Shuang Qi Yilin Wang Bo Jiang Yongcan Jin 

机构地区：[1]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,International Innovation Center for Forest Chemicals and Materials,Nanjing Forestry University,Nanjing 210037,China

出　　处：《Journal of Bioresources and Bioproducts》2025年第1期62-76,共15页生物质资源与工程(英文)

基　　金：financial support from National Natural Science Foundation of China(No.32201500;No.32271811);Natural Science Foundation of Jiangsu Province(No.BK20220431);Jiangsu Provincial Key Research and Development Program(No.BE2021368);the China Postdoctoral Science Foundation(No.2023M731708).

摘　　要：The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing.However,the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity.Herein,a controlled/sustained release polyvinyl alco-hol/chitosan/sulfonated lignin hydrogel(PVA-CS-L)integrated mechanical strengthening and bioactivities of lignin was developed.The lignin-induced non-covalent bond network(van der Waals force,hydrogen and electrostatic interactions)promoted energy dissipation when the hy-drogel was subjected to stretching and compression.This endowed the PVA-CS-L hydrogel with improved tensile(∼36 kPa)and compressive strength(∼900 kPa),as well as compressive tough-ness(∼9.0 MJ/m^(3)),which were superior to the polyvinyl alcohol/chitosan hydrogel(PVA-CS)(31 kPa,680 kPa,and 7.5 MJ/m^(3),respectively).The construction of electrostatic interaction could not only slow down the sudden release of lignin but also make the hydrogel exhibit a good pH-sensitive behavior of controlled-release lignin.Also,the developed hydrogel had good biocom-patibility and the released lignin had reactive oxygen species scavenging as well as inhibitory activity against Staphylococcus aureus.Finally,preliminary evaluation of drug delivery reveals that the presence of lignin enabled the hydrogel to exhibit longer-lasting controlled/sustained epigallocatechin gallate release properties.Such lignin-based controlled/sustained release hydro-gel that integrates the molecular structure and biological difunctional features of lignin gives new insight into cost-effective,easy-to-operate manufacturing of load-bearing and bioactive materials.

关 键 词：LIGNIN HYDROGEL Controlled/sustained release Mechanical strengthening Bioactivity 

分 类 号：O63[理学—高分子化学]