食源性复方人参水提物的抗疲劳作用  

Anti-fatigue effect of food-derived compound ginseng aqueous extracts

作　　者：熊武青 麻秀萍 郭江涛 白志文 罗仕西 XIONG Wuqing;MA Xiuping;GUO Jiangtao;BAI Zhiwen;LUO Shixi(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550025,China;National Engineering and Technology Research Centre for Miao Medicine,Guiyang,Guizhou 550025,China;Guizhou Engineering and Technology Research Centre for Chinese Medicine Concoction and Preparation,Guiyang,Guizhou 550025,China;Research Centre for Tea and Healthy Foods Development,Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550025,China;Guizhou Wucha Healthy Industry Development Co.,Ltd.,Guiyang,Guizhou 550002,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025 [2]国家苗药工程技术研究中心,贵州贵阳550025 [3]贵州中药炮制与制剂工程技术研究中心,贵州贵阳550025 [4]贵州中医药大学茶+大健康食品开发研究中心,贵州贵阳550025 [5]贵州吾茶大健康产业发展有限公司,贵州贵阳550002

出　　处：《食品与机械》2025年第1期180-185,共6页Food and Machinery

基　　金：贵州省科技计划项目(编号:黔科合支撑[2022]重点011号)。

摘　　要：[目的]探究药食同源中药人参、黄精、玉竹及陈皮复合水提物对小鼠抗疲劳作用的影响。[方法]该试验分为空白对照组、阳性对照组(大株红景天胶囊,0.70 g/kg)和复方人参水提物低、中、高(1.56,3.30,6.60 g/kg)剂量组,连续灌胃给药30 d。通过小鼠负重力竭游泳试验及肝糖原、血乳酸、血尿素氮等生化指标,评价复方人参水提物的抗疲劳作用。[结果]与空白对照组相比,复方人参水提物对小鼠正常生长及精神状态无显著影响(P>0.05)。中、高剂量组显著延长小鼠负重力竭游泳时间(P<0.05),高剂量组显著提高肝糖原水平(P<0.05),降低血乳酸、血尿素氮及丙二醛水平(P<0.05)。[结论]复方人参水提物有助于缓解小鼠运动疲劳,具有较强的抗疲劳作用。[Objective]To investigate the anti-fatigue effect of compound aqueous extracts of Ginseng Radix et Rhizoma,Polygonati Rhizoma,Polygonati Odorati Rhizoma,and Citri Reticulatae Pericarpium in mice.[Methods]The experiment included a blank control group,a positive control group(Rhodiola rosea capsules,0.70 g/kg),and low,medium,and high dose groups of compound ginseng aqueous extracts(1.56,3.30,and 6.60 g/kg,respectively),which were administered by gavage for 30 days.The anti-fatigue effect was evaluated using the weight-bearing exhaustion swimming test and by measuring biochemical markers,including hepatic glycogen,blood lactate,and blood urea nitrogen.[Results]Compared with the blank control group,the compound ginseng aqueous extracts had no significant effect on the normal weight gain or mental state of the mice(P>0.05).The medium and high dose groups significantly prolonged the swimming time during weight-bearing exhaustion(P<0.05).The high dose group significantly increased hepatic glycogen levels(P<0.05)and reduced blood lactate,blood urea nitrogen,and malondialdehyde levels(P<0.05).[Conclusion]The compound ginseng aqueous extracts help alleviate exercise-induced fatigue in mice and demonstrate strong anti-fatigue effect.

关 键 词：复方人参 抗疲劳 药食同源 负重力竭游泳 小鼠 

分 类 号：R285.5[医药卫生—中药学]