马来酸麦角新碱联合缩宫素预防剖宫产患者产后出血的效果  

Effect of Ergometrine Maleate Combined with Oxytocin on Prevention of Postpartum Hemorrhage in Patients with Cesarean Section

作　　者：梁霜 赵广蕊 LIANG Shuang;ZHAO Guangrui(Department of Obstetrics,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院产科,河南南阳473000

出　　处：《中国药物滥用防治杂志》2025年第1期104-107,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探究马来酸麦角新碱联合使用对预防剖宫产后出血的作用,同时分析用药后不良反应发生的影响因素。方法:选取本院于2023年6月—2024年6月期间接诊的84例行剖宫产产妇,按照入院顺序1∶1纳入常规组和联合治疗组,每组42例。常规组予以缩宫素治疗,联合治疗组在常规组基础上予以马来酸麦角新碱联合治疗。比较两组临床疗效、产后2 h和24 h的出血量、血红蛋白、凝血指标和不良反应发生率。单因素/多因素分析不良反应发生的影响因素。结果:联合治疗组(95.24%)总有效率高于常规组(73.81%),差异有统计学意义(P<0.05);联合治疗组产后2 h出血量、产后24 h出血量均低于常规组(P<0.05);联合治疗组手术后1 d血红蛋白水平高于常规组,凝血酶时间、凝血酶原时间和纤维蛋白原水平低于常规组(P<0.05);联合治疗组和常规组不良反应发生率比较,差异无统计学意义(P>0.05);Logistic回归模型分析显示,孕周、手术时间和产后出血量是剖宫产患者用药治疗后不良反应发生的危险因素(P<0.05)。结论:在剖宫产手术中应用马来酸麦角新碱与缩宫素联合方案,可以增强预防产后出血的效果,大幅降低产后出血量,更有效地稳定血红蛋白水平,还可优化凝血相关指标。孕周、手术时间和产后出血量是用药后不良反应发生的危险因素,临床应用时需综合评估产妇个体情况,以保障用药安全并提高预防产后出血效果。Objective:To explore the effect of combined use of ergonovine maleate on the prevention of hemorrhage after cesarean section,and to analyze the influencing factors of adverse reactions after medication.Methods:A total of 84 parturients who underwent cesarean section in our hospital from June 2023 to June 2024 were selected and included in the routine group and the combined treatment group according to the admission order of 1:1,with 42 parturients in each group.The conventional group was treated with oxytocin,and the combined treatment group was treated with ergometrine maleate on the basis of the conventional group.The clinical efficacy,bleeding volume at 2 h and 24 h after delivery,hemoglobin,coagulation index and incidence of adverse reactions were compared between the two groups.Univariate/multivariate analysis was used to analyze the influencing factors of adverse reactions.Results:The total effective rate of the combined treatment group(95.24%)was higher than that of the conventional group(73.81%),and the difference was statistically significant(P<0.05).The amount of bleeding at 2 h and 24 h after delivery in the combined treatment group were lower than those in the conventional group(P<0.05).The hemoglobin level at 1 d after operation in the combined treatment group was higher than that in the conventional group,and the thrombin time,prothrombin time and fibrinogen level were lower than those in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined treatment group and the conventional group(P>0.05).Logistic regression model analysis showed that gestational age,operation time and postpartum hemorrhage were risk factors for adverse reactions after drug treatment in cesarean section patients(P<0.05).Conclusion:The application of ergometrine maleate combined with oxytocin in cesarean section can enhance the effect of preventing postpartum hemorrhage,greatly reduce postpartum hemorrhage,stabilize hemoglobin level more effectively,and optimi

关 键 词：剖宫产 产后出血 马来酸麦角新碱 缩宫素 不良反应 

分 类 号：R714.461[医药卫生—妇产科学] R719.8[医药卫生—临床医学]