重组人脑利尿钠肽联合常规用药方案治疗急诊高血压伴心衰患者的效果  

Effect of Recombinant Human Brain Natriuretic Peptide Combined with Conventional Regimen in the Treatment of Emergency Hypertension Patients with Heart Failure

作　　者：刘世梅 靳志峰[1] 刘振 王晓丽 LIU Shimei;JIN Zhifeng;LIU Zhen;WANG Xiaoli(West District Hospital,Nanyang First People's Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市第一人民医院西区医院,河南南阳473000

出　　处：《中国药物滥用防治杂志》2025年第1期122-124,128,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨重组人脑利尿钠肽联合常规用药方案治疗急诊高血压伴心衰患者的效果。方法:选取2021年1月—2023年3月于本院就诊的162例急诊高血压伴心衰患者,按随机数字表法分为观察组(n=81)与对照组(n=81)。对照组给予常规用药方案治疗,观察组在对照组基础上给予重组人脑利尿钠肽治疗。比较两组左心功能指标、神经内分泌激素指标、血压和6min步行距离、血清指标、用药效果以及不良反应。结果:治疗后,观察组左心射血分数(LVEF)和左心室峰值充盈率(LVPFR)指标高于对照组,脑利尿钠肽低于对照组(P<0.05);观察组肾上腺素(NE)、血管紧张素Ⅱ(Ang Ⅱ)以及醛固酮(ALD)指标低于对照组(P<0.05);观察组6min步行距离(6MWT)高于对照组,血压低于对照组(P<0.05);观察组总有效率为95.06%,高于对照组的79.01%(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:重组人脑利尿钠肽联合常规用药方案治疗急诊高血压伴心衰患者能改善心功能,降低神经内分泌激素、血压水平,有较好的疗效且并未明显增加药物安全性的风险。Objective:To investigate the effect of recombinant human brain natriuretic peptide combined with conventional regimen in the treatment of emergency hypertension patients with heart failure.Methods:A total of 162 patients with emergency hypertension and heart failure who were treated in our hospital from January 2021 to March 2023 were selected and divided into observation group(n=81)and control group(n=81)according to the random number table method.The control group was treated with conventional medication,and the observation group was treated with recombinant human brain natriuretic peptide on the basis of the control group.The left ventricular function index,neuroendocrine hormone index,blood pressure and 6 min walking distance,serum index,medication effect and adverse reactions were compared between the two groups.Results:After treatment,the left ventricular ejection fraction(LVEF)and left ventricular peak filling rate(LVPFR)in the observation group were higher than those in the control group,and the brain natriuretic peptide was lower than that in the control group(P<0.05).The indexes of adrenaline(NE),angiotensinⅡ(AngⅡ)and aldosterone(ALD)in the observation group were lower than those in the control group(P<0.05).The 6 min walking distance(6MWT)of the observation group was higher than that of the control group,and the blood pressure was lower than that of the control group(P<0.05).The total effective rate of the observation group was 95.06%,which was higher than 79.01%of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:Recombinant human brain natriuretic peptide combined with conventional medication regimen can improve cardiac function,reduce neuroendocrine hormones and blood pressure levels in patients with emergency hypertension and heart failure.It has good efficacy and does not significantly increase the risk of drug safety.

关 键 词：急诊高血压 重组人脑利尿钠肽 心力衰竭 神经内分泌 

分 类 号：R54[医药卫生—心血管疾病]