Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities  

作　　者：Yi Zang Ruo-nan Sun Ran-qi Feng Hong-hui Zhu Xu-wen Li 

机构地区：[1]Key Laboratory of Agricultural Microbiomics and Precision Application(MARA),Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Key Laboratory of Agricultural Microbiome(MARA),State Key Laboratory of Applied Microbiology Southern China,Guangdong Microbial Culture Center,Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou,Guangdong 510070,China [2]State Key Laboratory of Chemical Biology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]DrugDiscovery Shandong Laboratory,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai,Shandong 264117,China [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2025年第4期443-469,共27页中国化学(英文版)

基　　金：the financial support by the National Key Research andDevelopmentProgramnofChina(No.2021YFF0502400);the National Natural Science Foundation of China(Nos.82022069,42076099);Guangdong special support program(No.2021JC06N628);Shandong Laboratory Program(SYS202205);Taishan Scholars Program(tsqn202312302);the CAS Youth Interdisciplinary Team,Fundamental Research Projects of Science&Technology Innovation and Development Plan in Yantai City(2023JCYJ057);GDAS's project of science and technology development(Nos.2021GDASYL-20210102009).

摘　　要：Terpenoids are a large and diverse family of secondary metabolites that have gained more attention from chemists and pharmacologists for their intriguing skeletons and broad biological activities,including anti-inflammatory,antitumoral,antimicrobial,and anti-viral effects.Based on the previous reviews,this review comprehensively summarized recent advances on bioactive terpenoids,focusing on their intriguing structural features and promising biological activities,covering literature from 2020 to 2023.In this review,532 terpenoids with remarkable chemical architectures and biological properties are classified into sesquiterpenoids(142),diterpenoids(129),sesterterpenoids(24),triterpenoids(52),and meroterpenoids(185),that were isolated from terrestrial and marine resources.This review would provide a reference for researchers to rapidly discover the interesting terpenoids for further study as promising drug leads.

关 键 词：Natural products TERPENOIDS Novel structures Biological activity Drug discovery 

分 类 号：O62[理学—有机化学]