Highly efficient layered Ir sub-nanoclusters for antibacterial application  

作　　者：Lini Yang Pengbo Zhu Tao Li Yueyue Jiao Xiangbin Cai Jialan Liang Hexin Zhang Ning Wang Xiaowen Chen Hongyang Liu 

机构地区：[1]Department of Chemistry,Liaoning University,66 Congshan Road,Shenyang 110036,China [2]Liaoning Dandong Ecological Environment Monitoring Center,Dandong 11800,China [3]State Key Laboratory of Coal Conversion,Institute Coal Chemistry,Chinese Academy of Sciences,Taiyuan 030001,China [4]National Energy Center for Coal to Clean Fuel,Synfuels China Co.,Ltd,Beijing 100871,China [5]Department of Physics and Center for Quantum Materials,Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,China [6]Shenyang National Laboratory for Materials Science,Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China

出　　处：《Nano Research》2025年第3期573-580,共8页纳米研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.22072162,U21B2092,22402210,22202213,and 21961160722);International Partnership Program of Chinese Academy of Sciences(No.172GJHZ2022028MI);Shenyang Young Talents Program(No.RC220155);Natural Science Foundation of Liaoning Province(No.2024-MS-05);Liaoning BaiQianWan Talents Program and Guangxi Collaborative Innovation Centre of Structure and Property for New Energy and Materials,Science Research,Technology Development Project of Guilin(No.20210102-4)。

摘　　要：Atomically dispersed nanozymes have garnered immense attention within the biomedical field,while precisely designing these nanozymes and elucidating their intricate structure-performance relationships of their structures and antibacterial performance remain the formidable challenges.Herein,we fabricated defect-rich graphene supported layered Ir cluster nanozymes for antibacterial applications.Steady-state kinetic experiments revealed that the layered Ir clusters exhibited the higher catalytic efficiency of 1.16 mM^(−1)·s^(−1)with 3,3′,5,5′-tetramethylbenzidine(TMB)and 0.18 mM^(−1)·s^(−1)with H_(2)O_(2),compared to Ir nanoparticle(0.55 and 0.1 mM^(−1)·s^(−1))and the atomically dispersed Ir single-atom nanozyme(SAzyme)(0.3 and 0.039 mM^(−1)·s^(−1))and other previously reported single-atom nanozymes.Moreover,both experimental results and density functional theory studies disclosed that the layered Ir clusters exhibited the enhanced ability to facilitate the conversion of hydrogen peroxide into hydroxyl free radicals,signifying the higher catalytic efficiency than that on Ir nanoparticles and Ir single-atoms.Notably,the Ir cluster nanozyme with robust peroxidase-like activity had 100%antimicrobial rate against E.coli and S.aureus,underscoring its potential applications in antibacterial fields.

关 键 词：defect-rich graphene Ir catalyst sub-nanocluster peroxidase-like activity antibacterial application 

分 类 号：O64[理学—物理化学]