FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis  

作　　者：Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lv Qian Ren Fei Liu Song Chen Fengxia Ma Tao Cheng Hui Cheng 

机构地区：[1]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China [2]CAMS Center for Stem Cell Medicine,PUMC Department of Stem Cell and Regenerative Medicine,Tianjin 300020,China

出　　处：《Science China(Life Sciences)》2025年第3期722-733,共12页中国科学(生命科学英文版)

基　　金：supported by the National Key Research and Development Program of China(2020YFE0203000,2021YFA1100900);the National Natural Science Foundation of China(92368202,82270120);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019,2022-I2M-2-001);the CAMS Fundamental Research Funds for Central Research Institutes(3332021093).

摘　　要：Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation,which is crucial for maintaining homeostasis.Acute infections can prompt a hematopoietic response known as emergency myelopoiesis.In this study,using a Candida albicans(C.albicans)infection model,we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates.Impaired myeloid hematopoiesis and immune cell production were evident,as proved by the decreased numbers of hematopoietic stem and progenitor cells(HSPCs)and granulocytes in the bone marrow of Fhl2-deficient mice.In conclusion,FHL2 regulated emergency myelopoiesis in response to C.albicans,affecting the host’s defense against pathogens.

关 键 词：fungal infection emergency myelopoiesis FHL2 

分 类 号：R331[医药卫生—人体生理学]