红核妇洁洗液联合乳酸菌阴道胶囊治疗老年性阴道炎的效果及对阴道微环境的影响  

Effect of Honghe Fujie lotion combined with Lactobacillus vaginal capsule on senile vaginitis and its influence on vaginal microenvironment

作　　者：任默 谭宏伟 师维雅 Ren Mo;Tan Hongwei;Shi Weiya(Department of Gynecology 1,Northwest Women's and Children's Hospital,Xi'an 710061,China;Department of Gynecology 4,Northwest Women's and Children's Hospital,Xi'an 710061,China)

机构地区：[1]西北妇女儿童医院妇一科,西安710061 [2]西北妇女儿童医院妇四科,西安710061

出　　处：《中国综合临床》2025年第1期8-13,共6页Clinical Medicine of China

基　　金：陕西省重点研发计划项目(2023-YBSF-395)。

摘　　要：目的探讨红核妇洁洗液联合乳酸菌阴道胶囊对老年性阴道炎的治疗效果及对阴道微环境、阴道灌洗液炎症因子的影响。方法回顾性选取2020年2月至2024年3月于西北妇女儿童医院妇一科就诊的122例老年性阴道炎患者为研究对象,将其中采用乳酸菌阴道胶囊治疗的60例纳入对照组,将予以乳酸菌阴道胶囊与红核妇洁洗液联合治疗的62例患者纳入联合组。观察两组患者的临床疗效,对比治疗前后阴道微环境和阴道灌洗液炎症因子的变化以及治疗期间的不良反应发生情况。符合正态分布的计量资料组间比较采用t检验,计数资料组间率的比较采用χ^(2)检验,等级资料比较采用秩和检验。结果联合组患者治疗结束后的总有效率(95.16%,59/62)高于对照组(85.33%,50/60),差异有统计学意义(χ^(2)=4.48,P=0.034);联合组与对照组患者治疗结束后肿瘤坏死因子α[(106.22±4.83)ng/L与(109.34±5.52)ng/L]、白细胞介素6[(4.19±1.14)ng/L与(4.98±1.42)ng/L]、Toll样受体2[(5.45±1.02)ng/L与(6.27±1.63)ng/L]、阴道pH值(pH值≤4.5分别为48、36例)、菌群多样性(1、2、3、4级分别为51、5、4、2例与32、17、7、4例)均低于治疗前[(145.27±6.01)ng/L与(146.19±6.52)ng/L,(13.54±2.21)ng/L与(13.47±2.35)ng/L,(10.21±2.14)ng/L与(10.34±2.11)ng/L,pH值≤4.5分别为0、0例,菌群多样性1、2、3、4级分别为9、26、15、12例与8、24、16、12例],差异均有统计学意义(统计量值分别为t=39.88、t=33.41、t=29.61、t=23.59、t=15.81、t=11.82、χ^(2)=78.32、χ^(2)=51.43、Z=48.77、Z=21.07,均P<0.001),且联合组低于对照组,差异有统计学意义(统计量值分别为t=3.33、t=3.39、t=3.34,χ^(2)=4.31、Z=10.27;P值分别为0.001、0.001、0.001、0.038、0.001);两组患者治疗结束后的阴道菌群密集度与治疗前比较,差异无统计学意义(χ^(2)=1.01,P=0.314);治疗期间两组患者的不良反应总发生率比较,差异无统计学意义(χ^(2)=0.18,P=0.675)�ObjectiveTo explore the therapeutic effect of Honghe Fujie lotion combined with Lactobacillus vaginal capsule on senile vaginitis and its influence on vaginal microenvironment and inflammatory factors in vaginal lavage fluid.MethodsFrom February 2020 to March 2024122 patients with senile vaginitis in.first department of gynecology of Northwest Women's and Children's Hospital were retrospectively selected as the study subjects.Among them,60 patients who adopted Lactobacillus vaginal capsule were included in control group,and 62 patients who received Lactobacillus vaginal capsule combined with Honghe Fujie lotion were enrolled as combined group.The clinical efficacy of the two groups of patients was observed,and the changes of vaginal microenvironment and vaginal lavage fluid inflammatory factors before and after treatment and occurrence of adverse reactions during treatment were compared.The t-test was used for comparing between groups of metric data that conform to normal distribution,theχ^(2) test was used for comparing between groups of count data,and the rank sum test was used for comparing between groups of rank data.ResultsThe combined group(95.16%,59/62)had higher total effective rate after the end of treatment than the control group(85.33%,50/60)(χ^(2)=4.48,P=0.034).The levels of tumor necrosis factor-α((106.22±4.83)ng/L,(109.34±5.52)ng/L),interleukin-6((4.19±1.14)ng/L,(4.98±1.42)ng/L)and Toll-like receptor-2((5.45±1.02)ng/L,(6.27±1.63)ng/L),vaginal pH value(PH≤4.5:48 cases,36 cases)and flora diversity(level 1,2,3,4:51,5,4,2 cases and 32,17,7,4 cases)in combined group and control group after the end of treatment were lower compared with before treatment((145.27±6.01,146.19±6.52)ng/L,(13.54±2.21,13.47±2.35)ng/L,(10.21±2.14,10.34±2.11),(PH≤4.5:0,0 case,flora diversity level 1,2,3,4:9,26,15,12 cases and 8,24,16,12 cases),the differences were statistically significant(statistical values were t=39.88,t=33.41,t=29.61,t=23.59,t=15.81,t=11.82,χ^(2)=78.32,χ^(2)=51.43,Z=48.77,and Z=21.07,respect

关 键 词：红核妇洁洗液 乳酸菌阴道胶囊 老年性阴道炎 阴道微环境 阴道灌洗液炎症因子 

分 类 号：R71[医药卫生—妇产科学]