维生素D与伴鼻息肉型慢性鼻窦炎的研究进展  

Research progress of Vitamin D in chronic rhinosinusitis with nasal polyps

作　　者：李心茹 马俭[1] Li Xinru;Ma Jian(Department of Otolaryngology Head and Neck Surgery,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院,南京市第一医院耳鼻咽喉头颈外科,南京210006

出　　处：《中国综合临床》2025年第1期76-80,共5页Clinical Medicine of China

摘　　要：伴鼻息肉型慢性鼻窦炎是一种常见的累及鼻腔和鼻窦的慢性炎性疾病,病因不明且临床治疗效果欠佳。维生素D除主要参与钙磷代谢外,还参与抗炎及免疫调节。本资料通过回顾近年来有关维生素D改善长期慢性炎症过程所致组织重塑、固有免疫和适应性免疫变化的研究,对维生素D抗鼻窦炎炎性过程的效应及分子机制进行综述。Chronic rhinosinusitis with nasal polyps is a common chronic inflammatory disease involving the nasal cavity and paranasal sinuses,with unknown etiology and poor clinical treatment effect.In addition to calcium and phosphorus metabolism,vitamin D is involved in immune modulation and anti-inflammatory responses.We review recent research on the improvement of tissue remodeling,innate and adaptive immune changes caused by long-term chronic inflammation with vitamin D,and summarizes the effects and molecular mechanisms of vitamin D on the inflammatory process of sinusitis.

关 键 词：慢性鼻窦炎 鼻息肉 维生素D 组织重塑 固有免疫 适应性免疫 

分 类 号：R76[医药卫生—耳鼻咽喉科]